Metastatic hepatocellular carcinoma to parotid glands

• Published in: The American journal of case reports 2014-08, Vol.15, p.343-347
• Main Authors: Elzouki, Abdel-Naser, Elkhider, Hisham, Yacout, Khalid, Al Muzrakchi, Ahmed, Al-Thani, Shaikah, Ismail, Omer
• Format: Article
• Language: English
• Subjects: Aged; Biopsy, Fine-Needle; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - secondary; Diagnosis, Differential; Fatal Outcome; Follow-Up Studies; Humans; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - pathology; Male; Neoplasm Staging; Parotid Gland - pathology; Parotid Neoplasms - diagnosis; Parotid Neoplasms - secondary; Radiography
• ISSN: 1941-5923; 1941-5923
• DOI: 10.12659/AJCR.890661

Male, 66. Hepatocellular carcinoma. Abdominal distension • painful right facial swelling • weight loss. -. -. -. Rare disease. Hepatocellular carcinoma is a common cancer, but it rarely metastasizes to the salivary glands. A review of the literature revealed only 5 reported cases of hepatocellular carcinoma metastatic to parotid glands. We here report an additional case of this rare association. A 66-year-old male with a background of type 2 diabetes mellitus and post-alcoholic decompensated liver cirrhosis presented with a progressively enlarging painful right facial swelling for 2 months that was eventually found to be due to hepatocellular carcinoma metastatic to the right parotid gland. Fine needle aspiration from the right parotid showed sheets and single malignant cells that were interpreted as carcinoma not otherwise specific. However, biopsy showed metastatic hepatocellular carcinoma into the right parotid gland. We report an additional case of the rare metastasis of hepatocellular carcinoma to the parotid glands. It should therefore be considered in a patient with decompensated liver cirrhosis presenting with a parotid swelling. Furthermore, the present case demonstrates the importance of the tissue biopsy for obtaining an accurate final diagnosis.