Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure

Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroenceph-alogr...

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Published in:Neural regeneration research 2013-09, Vol.8 (27), p.2566-2572
Main Authors: Wang, Yinxu, Wang, Xiaoming, Ke, Sha, Tan, Juan, Hu, Litian, Zhang, Yaodan, Cui, Wenjuan
Format: Article
Language:English
Subjects:
Animal experimentation
Chaos theory
Convulsions & seizures
Electroencephalography
Epilepsy
Fecal incontinence
Health aspects
Magnetic instruments
Prevention
Research and Report : Neurodegenerative Disease and Neural Regeneration
SD大鼠
Transcranial magnetic stimulation
仿真
低频
慢性
抗癫痫作用
磁模拟
腹腔注射
非线性动态
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container_issue 27
container_start_page 2566
container_title Neural regeneration research
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creator Wang, Yinxu
Wang, Xiaoming
Ke, Sha
Tan, Juan
Hu, Litian
Zhang, Yaodan
Cui, Wenjuan
description Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroenceph-alographic parameters in rats with chronic epilepsy and explored the mechanism underlying repeti-tive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was estab-lished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. Nonlinear elec-electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.
doi_str_mv 10.3969/j.issn.1673-5374.2013.27.008
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source Open Access: PubMed Central; Publicly Available Content Database
subjects Animal experimentation
Chaos theory
Convulsions & seizures
Electroencephalography
Epilepsy
Fecal incontinence
Health aspects
Magnetic instruments
Prevention
Research and Report : Neurodegenerative Disease and Neural Regeneration
SD大鼠
Transcranial magnetic stimulation
仿真
低频
慢性
抗癫痫作用
磁模拟
腹腔注射
非线性动态
title Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure
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