Cell cycle-related genes p57kip2, Cdk5 and Spin in the pathogenesis of neural tube defects

In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified several genes involved in the development of neural tube defects. In this study, we...

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Bibliographic Details
Published in:Neural regeneration research 2013-07, Vol.8 (20), p.1863-1871
Main Authors: Li, Xinjun, Yang, Zhong, Zeng, Yi, Xu, Hong, Li, Hongli, Han, Yangyun, Long, Xiaodong, You, Chao
Format: Article
Language:English
Subjects:
Abnormalities
Acids
Apoptosis
Cell cycle
Cell growth
Defects
Embryos
Gene expression
Genes
Genetic aspects
Health aspects
Identification and classification
Kinases
Metabolism
Neural tube
Neurosciences
Pathogenesis
Phase transitions
Phosphorylation
Protein synthesis
Proteins
Research and Report : Basic Research in Neural Regeneration
Signal transduction
Studies
发病机制
相关基因
神经管畸形
神经管缺陷
细胞凋亡
细胞周期
自旋
蛋白基因
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Summary:In the field of developmental neurobiology, accurate and ordered regulation of the cell cycle and apoptosis are crucial factors contributing to the normal formation of the neural tube. Preliminary studies identified several genes involved in the development of neural tube defects. In this study, we established a model of developmental neural tube defects by administration of retinoic acid to pregnant rats. Gene chip hybridization analysis showed that genes related to the cell cycle and apoptosis, signal transduction, transcription and translation regulation, energy and metabolism, heat shock, and matrix and cytoskeletal proteins were all involved in the formation of developmental neural tube defects. Among these, cell cycle-related genes were predominant. Retinoic acid treat-ment caused differential expression of three cell cycle-related genes p57kip2, Cdk5 and Spin, the expression levels of which were downregulated by retinoic acid and upregulated during normal neural tube formation. The results of this study indicate that cell cycle-related genes play an im-portant role in the formation of neural tube defects. P57kip2, Cdk5 and Spin may be critical genes in the pathogenesis of neural tube defects.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2013.20.005