Microelectronic neural bridging of toad nerves to restore leg function

The present study used a microelectronic neural bridge comprised of electrode arrays for neural signal detection, functional electrical stimulation, and a microelectronic circuit including signal amplifying, processing, and functional electrical stimulation to bridge two separate nerves, and to rest...

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Bibliographic Details
Published in:Neural regeneration research 2013-02, Vol.8 (6), p.546-553
Main Authors: Shen, Xiaoyan, Wang, Zhigong, Lv, Xiaoying, Huang, Zonghao
Format: Article
Language:English
Subjects:
Cellular signal transduction
Electrodes
Electromyography
Emerging Technology in Neural Regeneration
Experiments
Health aspects
Legs
Nerves
Nervous system
Neural stimulation
Neurosciences
Physiological aspects
Spinal cord
Toads
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Summary:The present study used a microelectronic neural bridge comprised of electrode arrays for neural signal detection, functional electrical stimulation, and a microelectronic circuit including signal amplifying, processing, and functional electrical stimulation to bridge two separate nerves, and to restore the lost function of one nerve. The left leg of one spinal toad was subjected to external mechanical stimulation and functional electrical stimulation driving. The function of the left leg of one spinal toad was regenerated to the corresponding leg of another spinal toad using a microelectronic neural bridge. Oscilloscope tracings showed that the electromyographic signals from controlled spinal toads were generated by neural signals that controlled the spinal toad, and there was a delay between signals. This study demonstrates that microelectronic neural bridging can be used to restore neural function between different injured nerves.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2013.06.008