Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats

Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion i...

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Bibliographic Details
Published in:Neural regeneration research 2014-06, Vol.9 (11), p.1122-1128
Main Authors: Ji, Xiangyu, Zhang, Li'na, Liu, Ran, Liu, Yingzhi, Song, Jianfang, Dong, He, Jia, Yanfang, Zhou, Zangong
Format: Article
Language:English
Subjects:
Apoptosis
Care and treatment
Carotid arteries
Cerebral ischemia
Complications and side effects
Ethanol
Genetic aspects
Ischemia
Laboratory animals
Microscopy
Mitochondria
Patient outcomes
Proteins
Proteomics
Reperfusion injury
Research and Report
Rodents
Veins & arteries
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Summary:Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our experimental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral ischemia-reperfusion injury.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.135314