Extrapulmonary sarcoidosis of liver and pancreas: a case report and review of literature

Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin, which can involve nearly all organs. In the case of an infrequent gastrointestinal tract involvement in systemic sarcoidosis, granulomas of the liver are most commonly described while isolated pancreatic sarcoid lesions...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2007-05, Vol.13 (17), p.2504-2509
Main Authors: Harder, Hermann, Büchler, Markus W, Fröhlich, Boris, Ströbel, Philipp, Bergmann, Frank, Neff, Wolfgang, Singer, Manfred V
Format: Article
Language:English
Subjects:
Aged
Biopsy
Case Report
Humans
Liver - pathology
Liver Diseases - diagnosis
Liver Diseases - pathology
Liver Diseases - therapy
Male
Pancreas - pathology
Pancreatic Diseases - diagnosis
Pancreatic Diseases - pathology
Pancreatic Diseases - therapy
Prognosis
Sarcoidosis - diagnosis
Sarcoidosis - pathology
Sarcoidosis - therapy
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Summary:Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin, which can involve nearly all organs. In the case of an infrequent gastrointestinal tract involvement in systemic sarcoidosis, granulomas of the liver are most commonly described while isolated pancreatic sarcoid lesions are rarely seen. We report a case of systemic sarcoidosis with exclusive extrapulmonal involvement of the liver and the pancreas in a 71-year-old white man. The diagnosis of liver involvement was confirmed by biopsy. Pancreatic surgery was needed because preoperative evaluation could not exclude pancreatic cancer and for biliary decompression. An extensive literature review of systemic sarcoidosis, focusing on reported cases with unusual presentation of sarcoidosis in the liver and the pancreas, its diagnosis, treatment, and prognosis was made.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v13.i17.2504