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Next Generation Ligand Binding Assays—Review of Emerging Real-Time Measurement Technologies
ABSTRACT Over the last few years, numerous ligand binding assay technologies that utilize real-time measurement have been introduced; however, an assemblage and evaluation of these technologies has not previously been published. Herein, we describe six emerging real-time measurement technologies: Ma...
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| Published in: | The AAPS journal 2014-09, Vol.16 (5), p.914-924 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c512t-9acbfb029ed02d8708e1a7a74f64347e7ef929b2ad1d9e014df3b1794d5e82fb3 |
| container_end_page | 924 |
| container_issue | 5 |
| container_start_page | 914 |
| container_title | The AAPS journal |
| container_volume | 16 |
| creator | Fraser, Stephanie Cameron, Mark O’Connor, Edward Schwickart, Martin Tanen, Michael Ware, Mark |
| description | ABSTRACT
Over the last few years, numerous ligand binding assay technologies that utilize real-time measurement have been introduced; however, an assemblage and evaluation of these technologies has not previously been published. Herein, we describe six emerging real-time measurement technologies: Maverick™, MX96 SPR™, NanoDLSay™, AMMP®/ViBE®, SoPrano™, and two Lab-on-a-Chip (LoC) microfluidic devices. The development stage gate of these technologies ranges from pre-commercial to commercially available. Due to the novelty, the application and utility of some of the technologies regarding bioanalysis are likely to evolve but it is our hope that this review will provide insight into the direction the development of real-time measurement technologies is moving and the vision of those that are taking us there. Following the technology discussions, a comprehensive summary table is presented. |
| doi_str_mv | 10.1208/s12248-014-9643-2 |
| format | article |
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Over the last few years, numerous ligand binding assay technologies that utilize real-time measurement have been introduced; however, an assemblage and evaluation of these technologies has not previously been published. Herein, we describe six emerging real-time measurement technologies: Maverick™, MX96 SPR™, NanoDLSay™, AMMP®/ViBE®, SoPrano™, and two Lab-on-a-Chip (LoC) microfluidic devices. The development stage gate of these technologies ranges from pre-commercial to commercially available. Due to the novelty, the application and utility of some of the technologies regarding bioanalysis are likely to evolve but it is our hope that this review will provide insight into the direction the development of real-time measurement technologies is moving and the vision of those that are taking us there. Following the technology discussions, a comprehensive summary table is presented.</description><identifier>ISSN: 1550-7416</identifier><identifier>EISSN: 1550-7416</identifier><identifier>DOI: 10.1208/s12248-014-9643-2</identifier><identifier>PMID: 25060773</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acoustics - instrumentation ; Animals ; Binding Sites ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology ; Drug Design ; Equipment Design ; Humans ; Kinetics ; Ligands ; Microfluidic Analytical Techniques - instrumentation ; Miniaturization ; Nanotechnology - instrumentation ; Pharmaceutical Preparations - chemistry ; Pharmaceutical Preparations - metabolism ; Pharmacology/Toxicology ; Pharmacy ; Protein Binding ; Review ; Review Article ; Surface Plasmon Resonance - instrumentation ; Technology, Pharmaceutical - instrumentation ; Theme: Emerging Technologies in the BioAnalytical Space Applied to Large Molecule Determinations</subject><ispartof>The AAPS journal, 2014-09, Vol.16 (5), p.914-924</ispartof><rights>American Association of Pharmaceutical Scientists 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-9acbfb029ed02d8708e1a7a74f64347e7ef929b2ad1d9e014df3b1794d5e82fb3</citedby><cites>FETCH-LOGICAL-c512t-9acbfb029ed02d8708e1a7a74f64347e7ef929b2ad1d9e014df3b1794d5e82fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147046/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147046/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25060773$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fraser, Stephanie</creatorcontrib><creatorcontrib>Cameron, Mark</creatorcontrib><creatorcontrib>O’Connor, Edward</creatorcontrib><creatorcontrib>Schwickart, Martin</creatorcontrib><creatorcontrib>Tanen, Michael</creatorcontrib><creatorcontrib>Ware, Mark</creatorcontrib><title>Next Generation Ligand Binding Assays—Review of Emerging Real-Time Measurement Technologies</title><title>The AAPS journal</title><addtitle>AAPS J</addtitle><addtitle>AAPS J</addtitle><description>ABSTRACT
Over the last few years, numerous ligand binding assay technologies that utilize real-time measurement have been introduced; however, an assemblage and evaluation of these technologies has not previously been published. Herein, we describe six emerging real-time measurement technologies: Maverick™, MX96 SPR™, NanoDLSay™, AMMP®/ViBE®, SoPrano™, and two Lab-on-a-Chip (LoC) microfluidic devices. The development stage gate of these technologies ranges from pre-commercial to commercially available. Due to the novelty, the application and utility of some of the technologies regarding bioanalysis are likely to evolve but it is our hope that this review will provide insight into the direction the development of real-time measurement technologies is moving and the vision of those that are taking us there. 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Over the last few years, numerous ligand binding assay technologies that utilize real-time measurement have been introduced; however, an assemblage and evaluation of these technologies has not previously been published. Herein, we describe six emerging real-time measurement technologies: Maverick™, MX96 SPR™, NanoDLSay™, AMMP®/ViBE®, SoPrano™, and two Lab-on-a-Chip (LoC) microfluidic devices. The development stage gate of these technologies ranges from pre-commercial to commercially available. Due to the novelty, the application and utility of some of the technologies regarding bioanalysis are likely to evolve but it is our hope that this review will provide insight into the direction the development of real-time measurement technologies is moving and the vision of those that are taking us there. Following the technology discussions, a comprehensive summary table is presented.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25060773</pmid><doi>10.1208/s12248-014-9643-2</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1550-7416 |
| ispartof | The AAPS journal, 2014-09, Vol.16 (5), p.914-924 |
| issn | 1550-7416 1550-7416 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4147046 |
| source | Open Access: PubMed Central; Springer Nature |
| subjects | Acoustics - instrumentation Animals Binding Sites Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Drug Design Equipment Design Humans Kinetics Ligands Microfluidic Analytical Techniques - instrumentation Miniaturization Nanotechnology - instrumentation Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmacology/Toxicology Pharmacy Protein Binding Review Review Article Surface Plasmon Resonance - instrumentation Technology, Pharmaceutical - instrumentation Theme: Emerging Technologies in the BioAnalytical Space Applied to Large Molecule Determinations |
| title | Next Generation Ligand Binding Assays—Review of Emerging Real-Time Measurement Technologies |
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