Cold stress induces antioxidants and Hsps in chicken immune organs

• Published in: Cell stress & chaperones 2014-09, Vol.19 (5), p.635-648
• Main Authors: Zhao, Fu Qing, Zhang, Zi Wei, Qu, Jian Ping, Yao, Hai Dong, Li, Ming, Li, Shu, Xu, Shi Wen
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants; Antioxidants - metabolism; Biochemistry; Biomedical and Life Sciences; Biomedicine; Bursa of fabricius; Cancer Research; Cell Biology; Chickens; Cold Temperature; Cold-Shock Response - physiology; Control groups; Cytokines; Glutathione Peroxidase - metabolism; Heat shock proteins; Heat-Shock Proteins - metabolism; Immune system; Immunology; Male; Malondialdehyde - metabolism; Messenger RNA; Neurosciences; Original Paper; Oxidative stress; Oxidative Stress - immunology; RNA, Messenger - genetics; Spleen; Superoxide Dismutase - metabolism
• ISSN: 1355-8145; 1466-1268
• DOI: 10.1007/s12192-013-0489-9

The aim of this study was to investigate the effects of cold stress on oxidative indexes, immune function, and the expression levels of heat shock protein (Hsp90, Hsp70, Hsp60, Hsp40, and Hsp27) in immune organs of chickens. Two hundred forty 15-day-old male chickens were randomly divided into 12 groups and kept under the temperature of (12 ± 1) °C for acute and chronic cold stress. There were one control group and five treatment groups for acute cold stress and three control groups and three treatment groups for chronic cold stress. The results showed that cold stress influence the activities of antioxidant enzymes in the immune organs. The activities of SOD and GSH-Px were first increased then decreased, and activity of total antioxidation capacity (T-AOC) was significantly decreased (P