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Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma
Somatic mutations in isocitrate dehydrogenase (IDH)1 and 2 have been identified in a subset of gliomas, rendering these tumors with elevated levels of “oncometabolite,” D-2-hydroxyglutarate (2HG). Herein, we report that 2HG can be precisely detected by magnetic resonance (MR) in human glioma specime...
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| Published in: | Journal of molecular medicine (Berlin, Germany) Germany), 2012-10, Vol.90 (10), p.1161-1171 |
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| container_issue | 10 |
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| container_title | Journal of molecular medicine (Berlin, Germany) |
| container_volume | 90 |
| creator | Kalinina, Juliya Carroll, Anne Wang, Liya Yu, Qiqi Mancheno, Danny E. Wu, Shaoxiong Liu, Frank Ahn, Jun He, Miao Mao, Hui Van Meir, Erwin G. |
| description | Somatic mutations in isocitrate dehydrogenase
(IDH)1
and
2
have been identified in a subset of gliomas, rendering these tumors with elevated levels of “oncometabolite,” D-2-hydroxyglutarate (2HG). Herein, we report that 2HG can be precisely detected by magnetic resonance (MR) in human glioma specimens and used as a reliable biomarker to identify this subset of tumors. Specifically, we developed a two-dimensional correlation spectroscopy resonance method to reveal the distinctive cross-peak pattern of 2HG in the complex metabolite nuclear MR spectra of brain tumor tissues. This study demonstrates the feasibility, specificity, and selectivity of using MR detection and quantification of 2HG for the diagnosis and classification of
IDH1/2
mutation-positive brain tumors. It further opens up the possibility of developing analogous non-invasive MR-based imaging and spectroscopy studies directly in humans in the neuro-oncology clinic. |
| doi_str_mv | 10.1007/s00109-012-0888-x |
| format | article |
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(IDH)1
and
2
have been identified in a subset of gliomas, rendering these tumors with elevated levels of “oncometabolite,” D-2-hydroxyglutarate (2HG). Herein, we report that 2HG can be precisely detected by magnetic resonance (MR) in human glioma specimens and used as a reliable biomarker to identify this subset of tumors. Specifically, we developed a two-dimensional correlation spectroscopy resonance method to reveal the distinctive cross-peak pattern of 2HG in the complex metabolite nuclear MR spectra of brain tumor tissues. This study demonstrates the feasibility, specificity, and selectivity of using MR detection and quantification of 2HG for the diagnosis and classification of
IDH1/2
mutation-positive brain tumors. It further opens up the possibility of developing analogous non-invasive MR-based imaging and spectroscopy studies directly in humans in the neuro-oncology clinic.</description><identifier>ISSN: 0946-2716</identifier><identifier>EISSN: 1432-1440</identifier><identifier>DOI: 10.1007/s00109-012-0888-x</identifier><identifier>PMID: 22426639</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Biomedical and Life Sciences ; Biomedicine ; Brain Neoplasms - diagnosis ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Child ; Child, Preschool ; DNA Mutational Analysis ; Female ; General aspects ; Glioma - diagnosis ; Glioma - genetics ; Glioma - metabolism ; Glutarates - metabolism ; Human Genetics ; Humans ; Internal Medicine ; Isocitrate Dehydrogenase - genetics ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical sciences ; Middle Aged ; Molecular Medicine ; Neurology ; Original Article ; Sensitivity and Specificity ; Tumors of the nervous system. Phacomatoses ; Young Adult</subject><ispartof>Journal of molecular medicine (Berlin, Germany), 2012-10, Vol.90 (10), p.1161-1171</ispartof><rights>Springer-Verlag 2012</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2012 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-a7cc3e91ece6c70c5d69748326c024eebd539c412fe20c4e7b9a3a175cdec5963</citedby><cites>FETCH-LOGICAL-c599t-a7cc3e91ece6c70c5d69748326c024eebd539c412fe20c4e7b9a3a175cdec5963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26335774$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22426639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalinina, Juliya</creatorcontrib><creatorcontrib>Carroll, Anne</creatorcontrib><creatorcontrib>Wang, Liya</creatorcontrib><creatorcontrib>Yu, Qiqi</creatorcontrib><creatorcontrib>Mancheno, Danny E.</creatorcontrib><creatorcontrib>Wu, Shaoxiong</creatorcontrib><creatorcontrib>Liu, Frank</creatorcontrib><creatorcontrib>Ahn, Jun</creatorcontrib><creatorcontrib>He, Miao</creatorcontrib><creatorcontrib>Mao, Hui</creatorcontrib><creatorcontrib>Van Meir, Erwin G.</creatorcontrib><title>Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma</title><title>Journal of molecular medicine (Berlin, Germany)</title><addtitle>J Mol Med</addtitle><addtitle>J Mol Med (Berl)</addtitle><description>Somatic mutations in isocitrate dehydrogenase
(IDH)1
and
2
have been identified in a subset of gliomas, rendering these tumors with elevated levels of “oncometabolite,” D-2-hydroxyglutarate (2HG). Herein, we report that 2HG can be precisely detected by magnetic resonance (MR) in human glioma specimens and used as a reliable biomarker to identify this subset of tumors. Specifically, we developed a two-dimensional correlation spectroscopy resonance method to reveal the distinctive cross-peak pattern of 2HG in the complex metabolite nuclear MR spectra of brain tumor tissues. This study demonstrates the feasibility, specificity, and selectivity of using MR detection and quantification of 2HG for the diagnosis and classification of
IDH1/2
mutation-positive brain tumors. It further opens up the possibility of developing analogous non-invasive MR-based imaging and spectroscopy studies directly in humans in the neuro-oncology clinic.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>General aspects</subject><subject>Glioma - diagnosis</subject><subject>Glioma - genetics</subject><subject>Glioma - metabolism</subject><subject>Glutarates - metabolism</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Isocitrate Dehydrogenase - genetics</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Neurology</subject><subject>Original Article</subject><subject>Sensitivity and Specificity</subject><subject>Tumors of the nervous system. 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(IDH)1
and
2
have been identified in a subset of gliomas, rendering these tumors with elevated levels of “oncometabolite,” D-2-hydroxyglutarate (2HG). Herein, we report that 2HG can be precisely detected by magnetic resonance (MR) in human glioma specimens and used as a reliable biomarker to identify this subset of tumors. Specifically, we developed a two-dimensional correlation spectroscopy resonance method to reveal the distinctive cross-peak pattern of 2HG in the complex metabolite nuclear MR spectra of brain tumor tissues. This study demonstrates the feasibility, specificity, and selectivity of using MR detection and quantification of 2HG for the diagnosis and classification of
IDH1/2
mutation-positive brain tumors. It further opens up the possibility of developing analogous non-invasive MR-based imaging and spectroscopy studies directly in humans in the neuro-oncology clinic.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22426639</pmid><doi>10.1007/s00109-012-0888-x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of molecular medicine (Berlin, Germany), 2012-10, Vol.90 (10), p.1161-1171 |
| issn | 0946-2716 1432-1440 |
| language | eng |
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| source | Springer Nature |
| subjects | Adult Aged Biological and medical sciences Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - metabolism Child Child, Preschool DNA Mutational Analysis Female General aspects Glioma - diagnosis Glioma - genetics Glioma - metabolism Glutarates - metabolism Human Genetics Humans Internal Medicine Isocitrate Dehydrogenase - genetics Magnetic Resonance Spectroscopy - methods Male Medical sciences Middle Aged Molecular Medicine Neurology Original Article Sensitivity and Specificity Tumors of the nervous system. Phacomatoses Young Adult |
| title | Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma |
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