Validation of the questionnaire for impulsive-compulsive disorders in Parkinson’s disease (QUIP) and the QUIP-rating scale in a German speaking sample

• Published in: Journal of neurology 2014-05, Vol.261 (5), p.936-942
• Main Authors: Probst, Catharina Claudia, Winter, Lina Marie, Möller, Bettina, Weber, Heinz, Weintraub, Daniel, Witt, Karsten, Deuschl, Günther, Katzenschlager, Regina, van Eimeren, Thilo
• Format: Article
• Language: English
• Subjects: Aged; Binge eating; Clinical medicine; Compulsive Behavior - diagnosis; Compulsive Behavior - psychology; Disruptive, Impulse Control, and Conduct Disorders - diagnosis; Disruptive, Impulse Control, and Conduct Disorders - psychology; Dopamine; Female; Gambling; German language; Germany - epidemiology; Humans; Likert scale; Male; Medicine; Medicine & Public Health; Middle Aged; Multilingualism; Neurology; Neuroradiology; Neurosciences; Original Communication; Parkinson Disease - diagnosis; Parkinson Disease - psychology; Parkinson's disease; Patients; Psychiatric Status Rating Scales - standards; Questionnaires; Surveys and Questionnaires
• ISSN: 0340-5354; 1432-1459
• DOI: 10.1007/s00415-014-7299-6

Impulsive-compulsive disorders are frequent in patients with Parkinson’s disease (PD). Recently, a screening questionnaire and rating scale were developed for these disorders: the questionnaire for impulsive-compulsive disorders (QUIP) and QUIP-rating scale (QUIP-RS). We assessed the validity of these instruments in the German language in order to reevaluate the benefit and to obtain German screening tools in clinical practice. A convenience sample of 156 patients was assessed in Kiel and Vienna. The patients filled out the QUIP-current, the QUIP-anytime and the QUIP-RS. We validated the questionnaires against a gold standard diagnosis via receiver operating characteristic curves and determined optimal cut-off scores for the instruments. Excluding walkabout, which was not shown to be valid, sensitivities ranged from 60–92 % for the QUIP-current, 68–91 % for the QUIP-anytime, and 73–100 % for the QUIP-RS. Specificities were >71 % for QUIP-current, >69 % for QUIP-anytime and >62 % for QUIP-RS. With its very good sensitivities, the QUIP-RS is a valid instrument to assess impulsive-compulsive disorders and makes an early detection of behavioral disorders in PD possible. The QUIP-anytime was also shown to be a valid screening instrument. Both are expected to prove useful in scientific and clinical practice.