Protective humoral immune response induced by an inactivated porcine reproductive and respiratory syndrome virus expressing the hypo-glycosylated glycoprotein 5

Highlights • Construction of mutant virus expressing hypo-glycosylated GP5 to develop inactivated vaccine. • Enhanced induction of serum neutralizing antibody response by inactivated mutant virus. • After homologous challenge, viremia was rapidly cleared in pigs immunized with the inactivated mutant...

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Bibliographic Details
Published in:Vaccine 2014-06, Vol.32 (29), p.3617-3622
Main Authors: Lee, Jung-Ah, Kwon, Byungjoon, Osorio, Fernando A, Pattnaik, Asit K, Lee, Nak-Hyung, Lee, Sang-Won, Park, Seung-Yong, Song, Chang-Seon, Choi, In-Soo, Lee, Joong-Bok
Format: Article
Language:English
Subjects:
Allergy and Immunology
Amino Acid Substitution
Amino acids
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Applied microbiology
Bacterial infections
Biological and medical sciences
Cloning
Fundamental and applied biological sciences. Psychology
Genomes
Glycosylation
GP5
Hogs
Humoral immune response
Hypo-glycosylation
Immune response
Immune system
Immunity, Humoral
Immunogenicity
Inactivated virus vaccine
Infections
Lung - immunology
Lung - pathology
Lymphocytes
Microbiology
Miscellaneous
Mutants
Neutralization Tests
Porcine Reproductive and Respiratory Syndrome - prevention & control
Porcine respiratory and reproductive syndrome virus
PRRSV
Studies
Swine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - immunology
Viral Envelope Proteins - genetics
Viral Envelope Proteins - immunology
Viral Vaccines - immunology
Viremia - prevention & control
Virology
Viruses
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Description
Summary:Highlights • Construction of mutant virus expressing hypo-glycosylated GP5 to develop inactivated vaccine. • Enhanced induction of serum neutralizing antibody response by inactivated mutant virus. • After homologous challenge, viremia was rapidly cleared in pigs immunized with the inactivated mutant virus. • Significantly reduced lymphocyte infiltration in lungs of pigs immunized with the inactivated mutant virus.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.04.083