Combination of percutaneous radiofrequency ablation with transarterial chemoembolization for hepatocellular carcinoma： observation of clinical effects

• Published in: Chinese journal of cancer research 2014-08, Vol.26 (4), p.471-477
• Main Authors: Liu, Hui-Chun, Shan, Er-Bo, Zhou, Lei, Jin, Hao, Cui, Pei-Yuan, Tan, Yi, Lu, Yi-Min
• Format: Article
• Language: English
• Subjects: Original; 临床效果; 临床治疗; 化疗; 原发性肝癌; 合并; 射频消融; 栓塞; 肝动脉
• ISSN: 1000-9604; 1993-0631
• DOI: 10.3978/j.issn.1000-9604.2014.08.18

Objective： To observe the clinical effect of radiofrequency ablation （RFA） combined with transcatheter arterial chemoembolization （TACE） for advanced hepatocellnlar carcinoma （HCC）. Methods： A total of 92 eases of advanced primary liver cancer underwent TACE and RFA treatment from June 2005 to 2011 at the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Bengbu Medical College. A total of 88 cases with complete clinical treatment and follow-up data were divided into two groups： 43 patients treated with TACE （TACE group） and 45 patients that received TACE combined with RFA treatment （TACE ＋ RFA group）. After clinical data assessment, tumor size and survival status were not significantly different between the groups as determined by stratified analysis. Results： Before and after surgery, spiral CT radiography and color comparison observed ablation conditions. The tumor necrosis rates after treatment （CR ＋ PR） were 67.4% （29/43） and 91.1% （41/45） for the TACE and combined treatment groups, respectively, and the difference was statistically significant （P〈0.05）. The quality of life was significantly improved for patients undergoing TACE ~ RFA compared with the control group. Survival duration was not significantly different in patients undergoing TACE ~ RFA compared with the control group. Conclusions： In this study, the effect of RFA combined with TACE treatment was better than TACE alone in treating advanced HCC.