VERMONT: Visualizing mutations and their effects on protein physicochemical and topological property conservation

In this paper, we propose an interactive visualization called VERMONT which tackles the problem of visualizing mutations and infers their possible effects on the conservation of physicochemical and topological properties in protein families. More specifically, we visualize a set of structure-based s...

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Bibliographic Details
Published in:BMC proceedings 2014-08, Vol.8 (Suppl 2 Proceedings of the 3rd Annual Symposium on Biologica), p.S4-S4, Article S4
Main Authors: Silveira, Sabrina A, Fassio, Alexandre V, Gonçalves-Almeida, Valdete M, de Lima, Elisa B, Barcelos, Yussif T, Aburjaile, Flávia F, Rodrigues, Laerte M, Meira, Jr, Wagner, de Melo-Minardi, Raquel C
Format: Article
Language:English
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Summary:In this paper, we propose an interactive visualization called VERMONT which tackles the problem of visualizing mutations and infers their possible effects on the conservation of physicochemical and topological properties in protein families. More specifically, we visualize a set of structure-based sequence alignments and integrate several structural parameters that should aid biologists in gaining insight into possible consequences of mutations. VERMONT allowed us to identify patterns of position-specific properties as well as exceptions that may help predict whether specific mutations could damage protein function.
ISSN:1753-6561
1753-6561
DOI:10.1186/1753-6561-8-S2-S4