The effect of progesterone level prior to oocyte retrieval on the numbers of oocytes retrieved and embryo quality in IVF treatment cycles: an analysis of 2,978 cycles

Purpose The study was designed to evaluate the relationship between serum progesterone (P4) response after hCG administration and the number of oocytes retrieved and the embryo quality in fresh IVF cycles. Methods We conducted a retrospective cohort study of women aged 24–43 years who underwent firs...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2014-09, Vol.31 (9), p.1183-1187
Main Authors: Zhu, Haiyan, Liu, Liu, Yang, Lingyun, Xue, Yamei, Tong, Xiaomei, Jiang, Lingying, Zhang, Songying
Format: Article
Language:English
Subjects:
Adult
Assisted Reproduction Technologies
Cohort analysis
Embryo, Mammalian - cytology
Embryos
Female
Fertilization in Vitro - methods
Gynecology
Human Genetics
Humans
In vitro fertilization
Laboratories
Medicine
Medicine & Public Health
Oocyte Retrieval
Ovaries
Patients
Pregnancy
Pregnancy Rate
Progesterone - blood
Reproductive Medicine
Retrospective Studies
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Summary:Purpose The study was designed to evaluate the relationship between serum progesterone (P4) response after hCG administration and the number of oocytes retrieved and the embryo quality in fresh IVF cycles. Methods We conducted a retrospective cohort study of women aged 24–43 years who underwent first fresh IVF cycle from 2011 to 2013 at a single practice. We compared the post-hCG serum P4 level with values on the day of hCG trigger. Patients were analyzed in long and short protocols independently. In addition, patients were stratified by post-hCG P4 response. Number of oocytes retrieved and embryo quality were the primary outcomes of interest. Ordinary least square regression models and logistic regression analysis models were created to identify predictive factors associated with embryological outcomes while adjusting for potential confounders. Results Among the 2,978 IVF cycles, 2,484 patients were in long protocols, and 494 patients were in short protocols. After adjusting for patient age, rFSH duration, and basal FSH levels, the associations between P4 response after hCG administration and number of oocytes retrieved ( P  
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-014-0291-3