Perspectives on antigen presenting cells in zebrafish

•The major APCs, dendritic cells, macrophages, and B cells, have been identified in zebrafish.•Functional studies indicate that hallmarks of mammalian APC activity are conserved in zebrafish.•Further research will advance our understanding of how APC function evolved in vertebrate animals. Antigen p...

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Bibliographic Details
Published in:Developmental and comparative immunology 2014-09, Vol.46 (1), p.63-73
Main Authors: Lewis, Kanako L., Del Cid, Natasha, Traver, David
Format: Article
Language:English
Subjects:
Animals
Antigen-presenting cells
Antigen-Presenting Cells - immunology
B lymphocytes
B-Lymphocytes - immunology
Danio rerio
Dendritic cells
Dendritic Cells - immunology
Histocompatibility Antigens - immunology
Macrophages
Macrophages - immunology
Vertebrates - immunology
Zebrafish
Zebrafish - immunology
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Summary:•The major APCs, dendritic cells, macrophages, and B cells, have been identified in zebrafish.•Functional studies indicate that hallmarks of mammalian APC activity are conserved in zebrafish.•Further research will advance our understanding of how APC function evolved in vertebrate animals. Antigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals, dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen presenting cells (APCs). Although APCs have been identified in zebrafish, it is unclear if they fulfill similar roles in the initiation of adaptive immunity. Here we review the characterization of zebrafish macrophages, DCs, and B cells and evidence of their function as true APCs. Finally, we discuss the conservation of APC activity in vertebrates and the use of zebrafish to provide a new perspective on the evolution of these functions.
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2014.03.010