Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase

Biocatalytic propane production: structure‐based engineering of aldehyde‐deformylating oxygenase improves specificity for short‐ and medium‐chain‐length aldehydes and enhances the propane generation in whole‐cell biotransformations. This presents new opportunities for developing biocatalytic modules...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2013-07, Vol.14 (10), p.1204-1208
Main Authors: Khara, Basile, Menon, Navya, Levy, Colin, Mansell, David, Das, Debasis, Marsh, E. Neil G., Leys, David, Scrutton, Nigel S.
Format: Article
Language:English
Subjects:
aldehyde decarbonylase
Aldehyde-Lyases - chemistry
Aldehydes - chemical synthesis
Aldehydes - chemistry
Alkanes - chemical synthesis
Alkanes - chemistry
Biocatalysis
Biofuels
Communications
decarbonylation
enzyme catalysis
Ligands
Propane - chemical synthesis
Propane - chemistry
specificity
Substrate Specificity
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Summary:Biocatalytic propane production: structure‐based engineering of aldehyde‐deformylating oxygenase improves specificity for short‐ and medium‐chain‐length aldehydes and enhances the propane generation in whole‐cell biotransformations. This presents new opportunities for developing biocatalytic modules for the production of volatile “drop‐in” biofuels.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201300307