Calcium and cholecalciferol supplementation provides no added benefit to nutritional counseling to improve bone mineral density in survivors of childhood acute lymphoblastic leukemia (ALL)

Background We sought to improve lumbar spine bone mineral density (LS‐BMD) in long‐term survivors of childhood acute lymphoblastic leukemia (ALL) using calcium and cholecalciferol supplementation. Procedure This double‐blind, placebo‐controlled trial randomized 275 participants (median age, 17 [9–36...

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Bibliographic Details
Published in:Pediatric blood & cancer 2014-05, Vol.61 (5), p.885-893
Main Authors: Kaste, S.C., Qi, A., Smith, K., Surprise, H., Lovorn, E., Boyett, J., Ferry Jr, R.J., Relling, M.V., Shurtleff, S.A., Pui, C.H., Carbone, L., Hudson, M.M., Ness, K.K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
ALL
Bone Density
Calcium
Calcium, Dietary - administration & dosage
Child
Child, Preschool
childhood cancer survivor
cholecalciferol
Cholecalciferol - administration & dosage
controlled trial
Counseling
Dietary Supplements
Double-Blind Method
Female
Follow-Up Studies
Hematology
Humans
Infant
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - physiopathology
Male
Nutrition Therapy
Older people
Oncology
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diet therapy
Survivors
Tomography, X-Ray Computed
vitamin D
Young Adult
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Summary:Background We sought to improve lumbar spine bone mineral density (LS‐BMD) in long‐term survivors of childhood acute lymphoblastic leukemia (ALL) using calcium and cholecalciferol supplementation. Procedure This double‐blind, placebo‐controlled trial randomized 275 participants (median age, 17 [9–36.1] years) with age‐ and gender‐specific LS‐BMD Z‐scores
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.24882