Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex

Although osteoporosis is known to alter bone tissue composition, the effects of such compositional changes on tissue material properties have not yet been examined. The natural gradient in tissue mineral content arising from skeletal appositional growth provides a basic model for investigation of re...

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Published in:Journal of biomedical materials research. Part A 2010-03, Vol.92A (3), p.1048-1056
Main Authors: Donnelly, Eve, Boskey, Adele L., Baker, Shefford P., van der Meulen, Marjolein C. H.
Format: Article
Language:English
Subjects:
Age
Aging
Animals
Biological and medical sciences
Bone and Bones - chemistry
Bone and Bones - ultrastructure
Bone Density
bone mineralization
Bones
Composition effects
Diseases of the osteoarticular system
Fundamental and applied biological sciences. Psychology
Hardness
Male
Mechanical properties
Medical sciences
Microscopy, Atomic Force
Nanocomposites
nanoindentation
Nanomaterials
Nanostructure
Nanotechnology
Osteoporosis. Osteomalacia. Paget disease
Raman spectroscopy
rat
Rats
Rats, Sprague-Dawley
Skeleton and joints
Spectrum Analysis, Raman
Vertebrates: osteoarticular system, musculoskeletal system
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container_issue 3
container_start_page 1048
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creator Donnelly, Eve
Boskey, Adele L.
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van der Meulen, Marjolein C. H.
description Although osteoporosis is known to alter bone tissue composition, the effects of such compositional changes on tissue material properties have not yet been examined. The natural gradient in tissue mineral content arising from skeletal appositional growth provides a basic model for investigation of relationships between tissue composition and mechanical properties. The purpose of this study was to examine the effects of tissue age on bone tissue composition and nanomechanical properties. The nanomechanical properties and composition of regions of differing tissue age were characterized in the femoral cortices of growing rats using nanoindentation and Raman spectroscopy. In addition, spatial maps of the properties of periosteal tissue were examined to investigate in detail the spatial gradients in the properties of newly formed tissue. Newly formed tissue (0–4 days) was 84% less stiff and had 79% lower mineral:matrix ratio than older intracortical (15–70 days) tissue. Tissue modulus, hardness, mineral:matrix ratio, and carbonate:phosphate ratio increased sharply with distance from the periosteum and attained the properties of intracortical tissue within 4 days of formation. The mineral: matrix ratio explained 54% and 62% of the variation in tissue indentation modulus and hardness, respectively. Our data demonstrate significant variations in tissue mechanical properties with tissue age and relate mechanical properties to composition at the microscale. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
doi_str_mv 10.1002/jbm.a.32442
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identifier ISSN: 1549-3296
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source Wiley-Blackwell Read & Publish Collection
subjects Age
Aging
Animals
Biological and medical sciences
Bone and Bones - chemistry
Bone and Bones - ultrastructure
Bone Density
bone mineralization
Bones
Composition effects
Diseases of the osteoarticular system
Fundamental and applied biological sciences. Psychology
Hardness
Male
Mechanical properties
Medical sciences
Microscopy, Atomic Force
Nanocomposites
nanoindentation
Nanomaterials
Nanostructure
Nanotechnology
Osteoporosis. Osteomalacia. Paget disease
Raman spectroscopy
rat
Rats
Rats, Sprague-Dawley
Skeleton and joints
Spectrum Analysis, Raman
Vertebrates: osteoarticular system, musculoskeletal system
title Effects of tissue age on bone tissue material composition and nanomechanical properties in the rat cortex
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