The Long Elusive IgM Fc Receptor, FcμR

IgM exists as both a monomer on the surface of B cells and a pentamer secreted by plasma cells. Both pre-immune “natural” and antigen-induced “immune” IgM antibodies are important for protective immunity and for immune regulation of autoimmune processes by recognizing pathogens and self-antigens. Ef...

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Published in:Journal of clinical immunology 2014-07, Vol.34 (Suppl 1), p.35-45
Main Authors: Kubagawa, Hiromi, Oka, Satoshi, Kubagawa, Yoshiki, Torii, Ikuko, Takayama, Eiji, Kang, Dong-Won, Jones, Dewitt, Nishida, Naonori, Miyawaki, Toshio, Bertoli, Luigi F., Sanders, Sheila K., Honjo, Kazuhito
Format: Article
Language:English
Subjects:
Animals
Autoantigens - immunology
B-Lymphocytes - immunology
Biomedical and Life Sciences
Biomedicine
Humans
Immunoglobulin M - immunology
Immunology
Immunomodulation
Infectious Diseases
Internal Medicine
Medical Microbiology
Mice
Receptors, Fc - immunology
Receptors, Fc - isolation & purification
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Summary:IgM exists as both a monomer on the surface of B cells and a pentamer secreted by plasma cells. Both pre-immune “natural” and antigen-induced “immune” IgM antibodies are important for protective immunity and for immune regulation of autoimmune processes by recognizing pathogens and self-antigens. Effector proteins interacting with the Fc portion of IgM, such as complement and complement receptors, have thus far been proposed but fail to fully account for the IgM-mediated protection and regulation. A major reason for this deficit in our understanding of IgM function seems to be lack of data on a long elusive Fc receptor for IgM (FcμR). We have recently identified a bona fide FcμR in both humans and mice. In this article we briefly review what we have learned so far about FcμR.
ISSN:0271-9142
1573-2592
DOI:10.1007/s10875-014-0022-7