Quadruple test parameters in art pregnancies

Quadruple test is used for Down's syndrome screening in the second trimester of pregnancy. The aim of this study was to investigate differences in quadruple test parameters between pregnancies achieved by assisted reproductive treatments (ART) and spontaneous conception. We retrospectively comp...

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Bibliographic Details
Published in:International journal of clinical and experimental medicine 2014-01, Vol.7 (8), p.2319-2323
Main Authors: Güdücü, Nilgün, Görmüş, Uzay, Güner, Ebru İlhan, Güzel, Omer, Kavak, Zehra Neşe
Format: Article
Language:English
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Summary:Quadruple test is used for Down's syndrome screening in the second trimester of pregnancy. The aim of this study was to investigate differences in quadruple test parameters between pregnancies achieved by assisted reproductive treatments (ART) and spontaneous conception. We retrospectively compared levels of alfa-fetoprotein (AFP), unconjugated Estriol (uE3), inhibin-A and hCG and also screen positive test results. Levels of all quadruple test parameters were statistically significantly increased in ART pregnancies when compared to spontaneous pregnancies, AFP was 1.4±0.74 and 1.16±0.53, (p=0.001), uE3 was 1.10±0.37 and 1.00±0.28, (p=0.004), hCG was 1.56±1.04 and 1.26±0.76, (p=0.001), inhibin A was 1.38±0.76 and 1.08±0.57, (p=0.001), screen positive tests were nearly doubled (4.8% and 8.4%). Increased screen positive test results and quadruple test parameters in ART pregnancies may lead to unnecessary amniocentesis.
ISSN:1940-5901
1940-5901