One in four individuals of African-American ancestry harbors a 5.5kb deletion at chromosome 11q13.1

Cloning and sequencing of 5.5kb deletion at chromosome 11q13.1 from the HeLa cells, tumorigenic hybrids and two fibroblast cell lines have revealed homologous recombination between AluSx and AluY resulting in the deletion of intervening sequences. Long-range PCR of the 5.5kb sequence in 494 normal l...

Full description

Saved in:
Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2014-04, Vol.103 (4), p.276-287
Main Authors: Zainabadi, Kayvan, Jain, Anuja V., Donovan, Frank X., Elashoff, David, Rao, Nagesh P., Murty, Vundavalli V., Chandrasekharappa, Settara C., Srivatsan, Eri S.
Format: Article
Language:English
Subjects:
5.5 kb deletion
African American ancestry
African Americans - genetics
Base Sequence
Cervical cancer
Chromosome 11q13.1
Chromosome Deletion
Chromosome Fragile Sites
Chromosomes, Human, Pair 11
Common fragile site
DNA Copy Number Variations
Female
Founder Effect
HapMap Project
HeLa Cells
Heterozygote
Humans
Linkage Disequilibrium
Male
Molecular Sequence Data
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cloning and sequencing of 5.5kb deletion at chromosome 11q13.1 from the HeLa cells, tumorigenic hybrids and two fibroblast cell lines have revealed homologous recombination between AluSx and AluY resulting in the deletion of intervening sequences. Long-range PCR of the 5.5kb sequence in 494 normal lymphocyte samples showed heterozygous deletion in 28.3% of African-American ancestry samples but only in 4.8% of Caucasian samples (p
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2014.01.001