Multifocal interferometric synthetic aperture microscopy

There is an inherent trade-off between transverse resolution and depth of field (DOF) in optical coherence tomography (OCT) which becomes a limiting factor for certain applications. Multifocal OCT and interferometric synthetic aperture microscopy (ISAM) each provide a distinct solution to the trade-...

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Bibliographic Details
Published in:Optics express 2014-06, Vol.22 (13), p.16606-16618
Main Authors: Xu, Yang, Chng, Xiong Kai Benjamin, Adie, Steven G, Boppart, Stephen A, Carney, P Scott
Format: Article
Language:English
Subjects:
Algorithms
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Interferometry - instrumentation
Microscopy, Interference - instrumentation
Tomography, Optical Coherence - instrumentation
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Summary:There is an inherent trade-off between transverse resolution and depth of field (DOF) in optical coherence tomography (OCT) which becomes a limiting factor for certain applications. Multifocal OCT and interferometric synthetic aperture microscopy (ISAM) each provide a distinct solution to the trade-off through modification to the experiment or via post-processing, respectively. In this paper, we have solved the inverse problem of multifocal OCT and present a general algorithm for combining multiple ISAM datasets. Multifocal ISAM (MISAM) uses a regularized combination of the resampled datasets to bring advantages of both multifocal OCT and ISAM to achieve optimal transverse resolution, extended effective DOF and improved signal-to-noise ratio. We present theory, simulation and experimental results.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.22.016606