Gonadal Steroids Negatively Modulate Oxidative Stress in CBA/Ca Female Mice Infected with P. berghei ANKA

We decreased the level of gonadal steroids in female and male mice by gonadectomy. We infected these mice with P. berghei ANKA and observed the subsequent impact on the oxidative stress response. Intact females developed lower levels of parasitaemia and lost weight faster than intact males. Gonadect...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-10
Main Authors: Morales-Montor, Jorge, Aguilar-Sánchez, Margarita, Buendía-González, Fidel Orlando, Rodríguez-Morales, Ana Laura, Mosqueda-Romo, Néstor Aarón, Legorreta-Herrera, Martha
Format: Article
Language:English
Subjects:
Anemia
Animals
Antioxidants
Antioxidants - analysis
Antioxidants - metabolism
Biomedical research
Body Weight - physiology
Female
Gender differences
Gonadal Steroid Hormones - metabolism
Gonads
Gonads - surgery
Malaria
Malaria - metabolism
Male
Mice
Mice, Inbred CBA
Nitric Oxide - analysis
Nitric Oxide - metabolism
Oxidative stress
Oxidative Stress - physiology
Parasites
Physiological aspects
Plasmodium berghei
Rodents
Steroid hormones
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Summary:We decreased the level of gonadal steroids in female and male mice by gonadectomy. We infected these mice with P. berghei ANKA and observed the subsequent impact on the oxidative stress response. Intact females developed lower levels of parasitaemia and lost weight faster than intact males. Gonadectomised female mice displayed increased levels of parasitaemia, increased body mass, and increased anaemia compared with their male counterparts. In addition, gonadectomised females exhibited lower specific catalase, superoxide dismutase, and glutathione peroxidase activities in their blood and spleen tissues compared with gonadectomised males. To further study the oxidative stress response in P. berghei ANKA-infected gonadectomised mice, nitric oxide levels were assessed in the blood and spleen, and MDA levels were assessed in the spleen. Intact, sham-operated, and gonadectomised female mice exhibited higher levels of nitric oxide in the blood and spleen compared with male mice. MDA levels were higher in all of the female groups. Finally, gonadectomy significantly increased the oxidative stress levels in females but not in males. These data suggest that differential oxidative stress is influenced by oestrogens that may contribute to sexual dimorphism in malaria.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/805495