The senescence-associated secretory phenotype: the dark side of tumor suppression

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of...

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Bibliographic Details
Published in:Annual review of pathology 2010-01, Vol.5 (1), p.99-118
Main Authors: Coppé, Jean-Philippe, Desprez, Pierre-Yves, Krtolica, Ana, Campisi, Judith
Format: Article
Language:English
Subjects:
Cell Transformation, Neoplastic - pathology
Cellular Senescence - physiology
Fibroblasts - pathology
Humans
Neoplasms - pathology
Neoplasms - physiopathology
Phenotype
Tumor Suppressor Proteins - physiology
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Summary:Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.
ISSN:1553-4006
1553-4014
DOI:10.1146/annurev-pathol-121808-102144