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Intracortical Remodeling Parameters Are Associated With Measures of Bone Robustness
ABSTRACT Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue‐level mechanical properties to incr...
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| Published in: | Anatomical record (Hoboken, N.J. : 2007) N.J. : 2007), 2014-10, Vol.297 (10), p.1817-1828 |
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| container_title | Anatomical record (Hoboken, N.J. : 2007) |
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| creator | Goldman, Haviva M. Hampson, Naomi A. Guth, J. Jared Lin, David Jepsen, Karl J. |
| description | ABSTRACT
Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue‐level mechanical properties to increase stiffness of slender bones and to reduce mass of robust bones. To further understand this association, we tested the hypothesis that the relationship between robustness and porosity is mediated through intracortical, BMU‐based (basic multicellular unit) remodeling. We quantified cortical porosity, mineralization, and histomorphometry at two sites (38% and 66% of the length) in human cadaveric tibiae. We found significant correlations between robustness and several histomorphometric variables (e.g., % secondary tissue [R2 = 0.68, P |
| doi_str_mv | 10.1002/ar.22962 |
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Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue‐level mechanical properties to increase stiffness of slender bones and to reduce mass of robust bones. To further understand this association, we tested the hypothesis that the relationship between robustness and porosity is mediated through intracortical, BMU‐based (basic multicellular unit) remodeling. We quantified cortical porosity, mineralization, and histomorphometry at two sites (38% and 66% of the length) in human cadaveric tibiae. We found significant correlations between robustness and several histomorphometric variables (e.g., % secondary tissue [R2 = 0.68, P < 0.004], total osteon area [R2 = 0.42, P < 0.04]) at the 66% site. Although these associations were weaker at the 38% site, significant correlations between histological variables were identified between the two sites indicating that both respond to the same global effects and demonstrate a similar character at the whole bone level. Thus, robust bones tended to have larger and more numerous osteons with less infilling, resulting in bigger pores and more secondary bone area. These results suggest that local regulation of BMU‐based remodeling may be further modulated by a global signal associated with robustness, such that remodeling is suppressed in slender bones but not in robust bones. Elucidating this mechanism further is crucial for better understanding the complex adaptive nature of the skeleton, and how interindividual variation in remodeling differentially impacts skeletal aging and an individuals' potential response to prophylactic treatments. Anat Rec, 297:1817–1828, 2014. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 1932-8486</identifier><identifier>EISSN: 1932-8494</identifier><identifier>DOI: 10.1002/ar.22962</identifier><identifier>PMID: 24962664</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Bone Density - physiology ; complex adaptive system ; cortical bone ; Female ; Humans ; Male ; Middle Aged ; porosity ; remodeling ; robustness ; Tibia - diagnostic imaging ; X-Ray Microtomography</subject><ispartof>Anatomical record (Hoboken, N.J. : 2007), 2014-10, Vol.297 (10), p.1817-1828</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5412-a3aeb6d711a27f70ede2aab2be0e309bc9755c93ec236a5c00547cb519a6e8403</citedby><cites>FETCH-LOGICAL-c5412-a3aeb6d711a27f70ede2aab2be0e309bc9755c93ec236a5c00547cb519a6e8403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24962664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldman, Haviva M.</creatorcontrib><creatorcontrib>Hampson, Naomi A.</creatorcontrib><creatorcontrib>Guth, J. Jared</creatorcontrib><creatorcontrib>Lin, David</creatorcontrib><creatorcontrib>Jepsen, Karl J.</creatorcontrib><title>Intracortical Remodeling Parameters Are Associated With Measures of Bone Robustness</title><title>Anatomical record (Hoboken, N.J. : 2007)</title><addtitle>Anat Rec (Hoboken)</addtitle><description>ABSTRACT
Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue‐level mechanical properties to increase stiffness of slender bones and to reduce mass of robust bones. To further understand this association, we tested the hypothesis that the relationship between robustness and porosity is mediated through intracortical, BMU‐based (basic multicellular unit) remodeling. We quantified cortical porosity, mineralization, and histomorphometry at two sites (38% and 66% of the length) in human cadaveric tibiae. We found significant correlations between robustness and several histomorphometric variables (e.g., % secondary tissue [R2 = 0.68, P < 0.004], total osteon area [R2 = 0.42, P < 0.04]) at the 66% site. Although these associations were weaker at the 38% site, significant correlations between histological variables were identified between the two sites indicating that both respond to the same global effects and demonstrate a similar character at the whole bone level. Thus, robust bones tended to have larger and more numerous osteons with less infilling, resulting in bigger pores and more secondary bone area. These results suggest that local regulation of BMU‐based remodeling may be further modulated by a global signal associated with robustness, such that remodeling is suppressed in slender bones but not in robust bones. Elucidating this mechanism further is crucial for better understanding the complex adaptive nature of the skeleton, and how interindividual variation in remodeling differentially impacts skeletal aging and an individuals' potential response to prophylactic treatments. Anat Rec, 297:1817–1828, 2014. © 2014 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Bone Density - physiology</subject><subject>complex adaptive system</subject><subject>cortical bone</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>porosity</subject><subject>remodeling</subject><subject>robustness</subject><subject>Tibia - diagnostic imaging</subject><subject>X-Ray Microtomography</subject><issn>1932-8486</issn><issn>1932-8494</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkdtL3UAQhxdRvFXwL5AFX_oS3Vs22ZfCqXgDpeW04uMy2czRlSRrd5OK_705Hj1eoPRpBubjY2Z-hOxydsAZE4cQD4QwWqyQTW6kyEpl1OqyL_UG2UrpjrFcMSPXyYZQI6y12iS_zrs-ggux9w4aOsU21Nj47ob-hAgt9hgTnUSkk5SC89BjTa99f0svEdIQMdEwo99Dh3QaqiH1Hab0hazNoEm481K3ydXJ8e-js-zix-n50eQic7niIgMJWOm64BxEMSsY1igAKlEhQ8lM5UyR585IdEJqyN18_cJVOTegsVRMbpNvC-_9ULVYO5yf0tj76FuIjzaAtx8nnb-1N-GvVVwXQshR8PVFEMOfAVNvW58cNg10GIZkuRZCs5IV6v9oPn-olNqM6P4n9C4MsRs_8Uwxw3JRvgldDClFnC335szOQ7UQ7XOoI7r3_s4l-JriCGQL4ME3-PhPkZ1MF8Inai-qrA</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Goldman, Haviva M.</creator><creator>Hampson, Naomi A.</creator><creator>Guth, J. 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Jared</au><au>Lin, David</au><au>Jepsen, Karl J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracortical Remodeling Parameters Are Associated With Measures of Bone Robustness</atitle><jtitle>Anatomical record (Hoboken, N.J. : 2007)</jtitle><addtitle>Anat Rec (Hoboken)</addtitle><date>2014-10</date><risdate>2014</risdate><volume>297</volume><issue>10</issue><spage>1817</spage><epage>1828</epage><pages>1817-1828</pages><issn>1932-8486</issn><eissn>1932-8494</eissn><abstract>ABSTRACT
Prior work identified a novel association between bone robustness and porosity, which may be part of a broader interaction whereby the skeletal system compensates for the natural variation in robustness (bone width relative to length) by modulating tissue‐level mechanical properties to increase stiffness of slender bones and to reduce mass of robust bones. To further understand this association, we tested the hypothesis that the relationship between robustness and porosity is mediated through intracortical, BMU‐based (basic multicellular unit) remodeling. We quantified cortical porosity, mineralization, and histomorphometry at two sites (38% and 66% of the length) in human cadaveric tibiae. We found significant correlations between robustness and several histomorphometric variables (e.g., % secondary tissue [R2 = 0.68, P < 0.004], total osteon area [R2 = 0.42, P < 0.04]) at the 66% site. Although these associations were weaker at the 38% site, significant correlations between histological variables were identified between the two sites indicating that both respond to the same global effects and demonstrate a similar character at the whole bone level. Thus, robust bones tended to have larger and more numerous osteons with less infilling, resulting in bigger pores and more secondary bone area. These results suggest that local regulation of BMU‐based remodeling may be further modulated by a global signal associated with robustness, such that remodeling is suppressed in slender bones but not in robust bones. Elucidating this mechanism further is crucial for better understanding the complex adaptive nature of the skeleton, and how interindividual variation in remodeling differentially impacts skeletal aging and an individuals' potential response to prophylactic treatments. Anat Rec, 297:1817–1828, 2014. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24962664</pmid><doi>10.1002/ar.22962</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Adult Bone Density - physiology complex adaptive system cortical bone Female Humans Male Middle Aged porosity remodeling robustness Tibia - diagnostic imaging X-Ray Microtomography |
| title | Intracortical Remodeling Parameters Are Associated With Measures of Bone Robustness |
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