Prognostic significance of various biochemical parameters in acute organophosphorus poisoning

Organophosphorus (OP) compounds are a heterogeneous group of insecticides widely used in agricultural industry. These OP compounds are likely to have more adverse effects in developing countries like India due to its easy availability and less awareness which results in high morbidity and mortality....

Full description

Saved in:
Bibliographic Details
Published in:Toxicology international 2014-05, Vol.21 (2), p.167-171
Main Authors: Sumathi, M E, Kumar, S Harish, Shashidhar, K N, Takkalaki, Nandini
Format: Article
Language:English
Subjects:
Agricultural industry
Agrochemicals
Analysis
Cholinesterase
Cholinesterases
Developing countries
Health aspects
Insecticides
LDCs
Lipase
Observational studies
Organophosphorus compounds
Original
Physiological aspects
Poisoning
Prognosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Organophosphorus (OP) compounds are a heterogeneous group of insecticides widely used in agricultural industry. These OP compounds are likely to have more adverse effects in developing countries like India due to its easy availability and less awareness which results in high morbidity and mortality. 1. To estimate plasma cholinesterase, amylase, lipase and, creatine phosphokinase (CPK) in acute OP poisoning. 2. To correlate these biochemical parameters with plasma cholinesterase levels in OP poisoning. 3. To determine the use of a biochemical marker in predicting the severity of acute OP poisoning. A hospital based observational study was conducted on 53 subjects who have clinically diagnosed of acute OP poisoning and admitted in emergency unit of a tertiary care rural hospital. Subjects of either gender of all age-groups were included in the study. On admission, plasma cholinesterase, serum amylase, lipase and CPK were measured. Based on plasma cholinesterase activity at the time of admission, subjects were divided into three groups. Group I-having 20-50% of plasma cholinesterase activity; Group II-10-20% of plasma cholinesterase activity; and group III-
ISSN:0971-6580
0976-5131
DOI:10.4103/0971-6580.139800