NY-ESO-1 as a potential immunotherapeutic target in renal cell carcinoma

Novel immune therapies targeting tumor specific antigens are being developed. Our purpose was to determine expression of the cancer testes antigen NY-ESO-1 in renal cell carcinoma (RCC), as NY-ESO-1 targeting approaches, particularly adoptive cell therapy, have not been evaluated in this disease. We...

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Bibliographic Details
Published in:Oncotarget 2014-07, Vol.5 (14), p.5209-5217
Main Authors: Giesen, Eva, Jilaveanu, Lucia B, Parisi, Fabio, Kluger, Yuval, Camp, Robert L, Kluger, Harriet M
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - analysis
Antigens, Neoplasm - biosynthesis
Antigens, Neoplasm - immunology
Carcinoma, Renal Cell - immunology
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - therapy
Clinical Research Paper
Cohort Studies
Humans
Immunotherapy
Kidney Neoplasms - immunology
Kidney Neoplasms - pathology
Kidney Neoplasms - therapy
Membrane Proteins - analysis
Membrane Proteins - biosynthesis
Membrane Proteins - immunology
Molecular Targeted Therapy
Neoplasm Metastasis
Tissue Array Analysis
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Summary:Novel immune therapies targeting tumor specific antigens are being developed. Our purpose was to determine expression of the cancer testes antigen NY-ESO-1 in renal cell carcinoma (RCC), as NY-ESO-1 targeting approaches, particularly adoptive cell therapy, have not been evaluated in this disease. We employed tissue microarrays containing >300 unique RCC cases and adjacent benign renal tissue to determine NY-ESO-1 expression using a quantitative immunofluorescence method. In addition, we studied NY-ESO-1 expression in 35 matched primary and metastatic RCC specimens to assess concordance between different tumor sites. NY-ESO-1 was highly expressed in a subset of RCCs. Expression in primary RCC specimens was significantly higher than adjacent normal renal tissue (P
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.2101