Correlation analysis of liver tumor-associated genes with liver regeneration

To study at transcriptional level the similarities and differences of the physiological and biochemical activities between liver tumor (LT) and regenerating liver cells. LT-associated genes and their expression changes in LT were obtained from databases and scientific articles, and their expression...

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Published in:World journal of gastroenterology : WJG 2007-06, Vol.13 (24), p.3323-3332
Main Authors: Xu, Cun-Shuan, Zhang, Shou-Bing, Chen, Xiao-Guang, Rahman, Salman
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Cell Proliferation
Gene Expression Regulation, Neoplastic
Liver Cancer
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Liver Regeneration
Oligonucleotide Array Sequence Analysis
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
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Summary:To study at transcriptional level the similarities and differences of the physiological and biochemical activities between liver tumor (LT) and regenerating liver cells. LT-associated genes and their expression changes in LT were obtained from databases and scientific articles, and their expression profiles in rat liver regeneration (LR) were detected using Rat Genome 230 2.0 array. Subsequently their expression changes in LT and LR were compared and analyzed. One hundred and twenty one LT-associated genes were found to be LR-associated. Thirty four genes were up-regulated, and 14 genes were down-regulated in both LT and regenerating liver; 20 genes up-regulated in LT were down-regulated in regenerating liver; 21 up-regulated genes and 16 down-regulated genes in LT were up-regulated at some time points and down-regulated at others during LR. Results suggested that apoptosis activity suppressed in LT was still active in regenerating liver, and there are lots of similarities and differences between the LT and regenerating liver at the aspects of cell growth, proliferation, differentiation, migration and angiogenesis.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v13.i24.3323