Neuroprotective Effects of Lipoxin A4 in Central Nervous System Pathologies

Many diseases of the central nervous system are characterized and sometimes worsened by an intense inflammatory response in the affected tissue. It is now accepted that resolution of inflammation is an active process mediated by a group of mediators that can act in synchrony to switch the phenotype...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Rae, Giles Alexander, Bento, Allisson Freire, Forner, Stefânia, Martini, Alessandra Cadete
Format: Article
Language:English
Subjects:
Animals
Brain damage
Care and treatment
Central nervous system diseases
Central Nervous System Diseases - drug therapy
Central Nervous System Diseases - pathology
Humans
Inflammation
Lipids
Lipoxins - therapeutic use
Medical research
Medicine, Experimental
Metabolism
Nervous system
Neuroprotective agents
Neuroprotective Agents - therapeutic use
Review
Rodents
Spinal cord
Stroke
Studies
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Summary:Many diseases of the central nervous system are characterized and sometimes worsened by an intense inflammatory response in the affected tissue. It is now accepted that resolution of inflammation is an active process mediated by a group of mediators that can act in synchrony to switch the phenotype of cells, from a proinflammatory one to another that favors the return to homeostasis. This new genus of proresolving mediators includes resolvins, protectins, maresins, and lipoxins, the first to be discovered. In this short review we provide an overview of current knowledge into the cellular and molecular interactions of lipoxins in diseases of the central nervous system in which they appear to facilitate the resolution of inflammation, thus exerting a neuroprotective action.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/316204