Correlates of Leptin in Children with Chronic Kidney Disease

Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD). Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort o...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of pediatrics 2014-10, Vol.165 (4), p.825-829
Main Authors: Nehus, Edward, MD, Furth, Susan, MD, PhD, Warady, Bradley, MD, Mitsnefes, Mark, MD
Format: Article
Language:English
Subjects:
Adolescent
Body Mass Index
Child
Cholesterol, HDL - blood
Cohort Studies
Contrast Media - chemistry
Cross-Sectional Studies
Cytokines - blood
Dyslipidemias - blood
Female
Glomerular Filtration Rate
Humans
Insulin - blood
Insulin Resistance
Iohexol - chemistry
Leptin - blood
Linear Models
Male
Multivariate Analysis
Pediatrics
Renal Insufficiency, Chronic - blood
Risk Factors
Triglycerides - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD). Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels. Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex ( P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2014.06.030