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Correlates of Leptin in Children with Chronic Kidney Disease
Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD). Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort o...
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| Published in: | The Journal of pediatrics 2014-10, Vol.165 (4), p.825-829 |
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| container_title | The Journal of pediatrics |
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| creator | Nehus, Edward, MD Furth, Susan, MD, PhD Warady, Bradley, MD Mitsnefes, Mark, MD |
| description | Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD). Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels. Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex ( P |
| doi_str_mv | 10.1016/j.jpeds.2014.06.030 |
| format | article |
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Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels. Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex ( P < .001 for all). Leptin level also correlated positively with serum triglycerides and insulin resistance ( P < .001) and negatively with serum high-density lipoprotein cholesterol ( P = .002). Leptin level was not associated with glomerular filtration rate calculated using the plasma iohexol disappearance curve or inflammatory cytokines. In multivariate analysis, BMI, age, female sex, and serum triglyceride levels were significantly associated with serum leptin level. Conclusion Increased leptin production was associated with female sex, older age, and adiposity in children with mild to moderate CKD. Renal function was not associated with serum leptin level, indicating that decreased clearance does not contribute to elevated leptin levels.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2014.06.030</identifier><identifier>PMID: 25066063</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Body Mass Index ; Child ; Cholesterol, HDL - blood ; Cohort Studies ; Contrast Media - chemistry ; Cross-Sectional Studies ; Cytokines - blood ; Dyslipidemias - blood ; Female ; Glomerular Filtration Rate ; Humans ; Insulin - blood ; Insulin Resistance ; Iohexol - chemistry ; Leptin - blood ; Linear Models ; Male ; Multivariate Analysis ; Pediatrics ; Renal Insufficiency, Chronic - blood ; Risk Factors ; Triglycerides - blood</subject><ispartof>The Journal of pediatrics, 2014-10, Vol.165 (4), p.825-829</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>2014 Mosby, Inc. All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-bd34fee7a1ddba7fe746b4261371b08e789071c983279767cce72c8d9b04d4e13</citedby><cites>FETCH-LOGICAL-c584t-bd34fee7a1ddba7fe746b4261371b08e789071c983279767cce72c8d9b04d4e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25066063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nehus, Edward, MD</creatorcontrib><creatorcontrib>Furth, Susan, MD, PhD</creatorcontrib><creatorcontrib>Warady, Bradley, MD</creatorcontrib><creatorcontrib>Mitsnefes, Mark, MD</creatorcontrib><title>Correlates of Leptin in Children with Chronic Kidney Disease</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD). Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels. Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex ( P < .001 for all). Leptin level also correlated positively with serum triglycerides and insulin resistance ( P < .001) and negatively with serum high-density lipoprotein cholesterol ( P = .002). Leptin level was not associated with glomerular filtration rate calculated using the plasma iohexol disappearance curve or inflammatory cytokines. In multivariate analysis, BMI, age, female sex, and serum triglyceride levels were significantly associated with serum leptin level. Conclusion Increased leptin production was associated with female sex, older age, and adiposity in children with mild to moderate CKD. Renal function was not associated with serum leptin level, indicating that decreased clearance does not contribute to elevated leptin levels.</description><subject>Adolescent</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Cholesterol, HDL - blood</subject><subject>Cohort Studies</subject><subject>Contrast Media - chemistry</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines - blood</subject><subject>Dyslipidemias - blood</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Iohexol - chemistry</subject><subject>Leptin - blood</subject><subject>Linear Models</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Pediatrics</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Risk Factors</subject><subject>Triglycerides - blood</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkV9rFDEUxYNY7Fr9BILMoy8z3vyZZAa0UFZbSxd8UJ9DJrnjZpydrMlsZb-92W4t6kshEELOOffyO4S8olBRoPLtUA1bdKliQEUFsgIOT8iCQqtK2XD-lCwAGCu5UPKUPE9pAIBWADwjp6wGKUHyBXm3DDHiaGZMReiLFW5nPxX5LNd-dBGn4pef1_kVw-RtcePdhPvig09oEr4gJ70ZE768v8_It8uPX5efytXnq-vlxaq0dSPmsnNc9IjKUOc6o3pUQnaCScoV7aBB1bSgqG0bzlSrpLIWFbONazsQTiDlZ-T8mLvddRt0Fqc5mlFvo9-YuNfBeP3vz-TX-nu41YIqJUSbA97cB8Twc4dp1hufLI6jmTDskqa1lBkcu5Pyo9TGkFLE_mEMBX3grgd9x10fuGuQOnPPrtd_b_jg-QM6C94fBZg53XqMOlmPk0XnI9pZu-AfGXD-n9-OPjdixh-4xzSEXZxyBZrqxDToL4fqD83TXHhdM8l_A4vgqdQ</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Nehus, Edward, MD</creator><creator>Furth, Susan, MD, PhD</creator><creator>Warady, Bradley, MD</creator><creator>Mitsnefes, Mark, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>Correlates of Leptin in Children with Chronic Kidney Disease</title><author>Nehus, Edward, MD ; Furth, Susan, MD, PhD ; Warady, Bradley, MD ; Mitsnefes, Mark, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-bd34fee7a1ddba7fe746b4261371b08e789071c983279767cce72c8d9b04d4e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Cholesterol, HDL - blood</topic><topic>Cohort Studies</topic><topic>Contrast Media - chemistry</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines - blood</topic><topic>Dyslipidemias - blood</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Iohexol - chemistry</topic><topic>Leptin - blood</topic><topic>Linear Models</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Pediatrics</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Risk Factors</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nehus, Edward, MD</creatorcontrib><creatorcontrib>Furth, Susan, MD, PhD</creatorcontrib><creatorcontrib>Warady, Bradley, MD</creatorcontrib><creatorcontrib>Mitsnefes, Mark, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nehus, Edward, MD</au><au>Furth, Susan, MD, PhD</au><au>Warady, Bradley, MD</au><au>Mitsnefes, Mark, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlates of Leptin in Children with Chronic Kidney Disease</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>165</volume><issue>4</issue><spage>825</spage><epage>829</epage><pages>825-829</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Objective To investigate the relative associations of renal function, obesity, and inflammation with serum leptin levels in children with chronic kidney disease (CKD). Study design This was a cross-sectional analysis of 317 children from the Chronic Kidney Disease in Children study, a large cohort of pediatric patients with stage II-IV CKD. Linear regression modeling was used to evaluate the association of serum leptin level with glomerular filtration rate calculated using the plasma iohexol disappearance curve, demographics, body mass index (BMI), and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipid levels. Results In univariate analyses, elevated serum leptin level was significantly associated with increased BMI, older age, and female sex ( P < .001 for all). Leptin level also correlated positively with serum triglycerides and insulin resistance ( P < .001) and negatively with serum high-density lipoprotein cholesterol ( P = .002). Leptin level was not associated with glomerular filtration rate calculated using the plasma iohexol disappearance curve or inflammatory cytokines. In multivariate analysis, BMI, age, female sex, and serum triglyceride levels were significantly associated with serum leptin level. Conclusion Increased leptin production was associated with female sex, older age, and adiposity in children with mild to moderate CKD. Renal function was not associated with serum leptin level, indicating that decreased clearance does not contribute to elevated leptin levels.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25066063</pmid><doi>10.1016/j.jpeds.2014.06.030</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Freedom Collection |
| subjects | Adolescent Body Mass Index Child Cholesterol, HDL - blood Cohort Studies Contrast Media - chemistry Cross-Sectional Studies Cytokines - blood Dyslipidemias - blood Female Glomerular Filtration Rate Humans Insulin - blood Insulin Resistance Iohexol - chemistry Leptin - blood Linear Models Male Multivariate Analysis Pediatrics Renal Insufficiency, Chronic - blood Risk Factors Triglycerides - blood |
| title | Correlates of Leptin in Children with Chronic Kidney Disease |
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