Microbial-Derived Butyrate: An Oncometabolite or Tumor-Suppressive Metabolite?

Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intest...

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Bibliographic Details
Published in:Cell host & microbe 2014-08, Vol.16 (2), p.143-145
Main Authors: Bultman, Scott J., Jobin, Christian
Format: Article
Language:English
Subjects:
Animals
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Dietary Carbohydrates - metabolism
MutS Homolog 2 Protein - metabolism
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Summary:Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cells, suggesting that it can act as an oncometabolite.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2014.07.011