The Melanogenesis-Inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1

Ginsenoside Rb1 (Rb1) is the most predominant ginsenoside isolated from the roots of ginseng ( Panax ginseng C. A. Meyer). This compound is active in various human biological pathways that are involved in human collagen synthesis and inhibition of cell apoptosis. In this study, the skin-whitening ef...

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Bibliographic Details
Published in:AAPS PharmSciTech 2014-10, Vol.15 (5), p.1252-1262
Main Authors: Wang, Lin, Lu, Ai-Ping, Yu, Zhi-Ling, Wong, Ricky N. S., Bian, Zhao-Xiang, Kwok, Hoi-Hin, Yue, Patrick Ying-Kit, Zhou, Li-Min, Chen, HuBiao, Xu, Min, Yang, Zhijun
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Cell Line, Tumor
Cell Survival
Collagen
Delayed-Action Preparations
Ginsenosides - administration & dosage
Ginsenosides - therapeutic use
Humans
Hyperpigmentation - drug therapy
In Vitro Techniques
Melanins - antagonists & inhibitors
Melanins - biosynthesis
Melanoma, Experimental - drug therapy
Melanoma, Experimental - metabolism
Monophenol Monooxygenase - metabolism
Panax ginseng
Permeability
Pharmacology/Toxicology
Pharmacy
Research Article
Swine
Transdermal Patch
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Summary:Ginsenoside Rb1 (Rb1) is the most predominant ginsenoside isolated from the roots of ginseng ( Panax ginseng C. A. Meyer). This compound is active in various human biological pathways that are involved in human collagen synthesis and inhibition of cell apoptosis. In this study, the skin-whitening effects of Rb1 were investigated in B16 melanoma cells. Our results showed that Rb1 inhibited melanogenesis in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16 cells in a dose-dependent manner, which collectively indicated that Rb1 may have skin-whitening effects and may be formulated into skin-whitening products for skin care. Accordingly, a ginsenoside collagen transdermal patch was developed as a vehicle to topically deliver Rb1 into pig skin. The percutaneous permeation, retention within skin, and release in vitro of Rb1 from seven transdermal patch formulas were studied. It was determined that the best formula for ginsenoside collagen transdermal patch is made of protein collagen hydrolysate powder (PCHP) 2.0% ( w / w ), methyl cellulose (MC) 0.5% ( w / w ), polyethyleneglycol 6000 (PEG6000) 0.5% ( w / w ), ginsenoside 0.036% ( w / w ), azone 0.4% ( v / w ), menthol 0.20% ( w / w ), and water.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-014-0138-3