Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo

Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative disease. Furthermore, the effects of ar-turmerone on neural stem cells (NSCs) remain to...

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Published in:Stem cell research & therapy 2014-09, Vol.5 (4), p.100-100, Article 100
Main Authors: Hucklenbroich, Joerg, Klein, Rebecca, Neumaier, Bernd, Graf, Rudolf, Fink, Gereon Rudolf, Schroeter, Michael, Rueger, Maria Adele
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cell Proliferation - drug effects
Cells, Cultured
Drug Evaluation, Preclinical
Injections, Intraventricular
Ketones - administration & dosage
Ketones - pharmacology
Male
Neural Stem Cells - drug effects
Neural Stem Cells - physiology
Neuroprotective Agents - administration & dosage
Neuroprotective Agents - pharmacology
Rats, Wistar
Sesquiterpenes - administration & dosage
Sesquiterpenes - pharmacology
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Summary:Aromatic (ar-) turmerone is a major bioactive compound of the herb Curcuma longa. It has been suggested that ar-turmerone inhibits microglia activation, a property that may be useful in treating neurodegenerative disease. Furthermore, the effects of ar-turmerone on neural stem cells (NSCs) remain to be investigated. We exposed primary fetal rat NSCs to various concentrations of ar-turmerone. Thereafter, cell proliferation and differentiation potential were assessed. In vivo, naïve rats were treated with a single intracerebroventricular (i.c.v.) injection of ar-turmerone. Proliferative activity of endogenous NSCs was assessed in vivo, by using noninvasive positron emission tomography (PET) imaging and the tracer [(18)F]-fluoro-L-thymidine ([(18)F]FLT), as well as ex vivo. In vitro, ar-turmerone increased dose-dependently the number of cultured NSCs, because of an increase in NSC proliferation (P 
ISSN:1757-6512
1757-6512
DOI:10.1186/scrt500