Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection

A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two...

Full description

Saved in:
Bibliographic Details
Published in:Retrovirology 2014-09, Vol.11 (1), p.69-69, Article 69
Main Authors: Ritchie, Adam John, Cai, Fangping, Smith, Nicola M G, Chen, Sheri, Song, Hongshuo, Brackenridge, Simon, Abdool Karim, Salim S, Korber, Bette T, McMichael, Andrew J, Gao, Feng, Goonetilleke, Nilu
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Acute Disease
acute infection
Adult
AIDS
Analysis
BASIC BIOLOGICAL SCIENCES
CD8-Positive T-Lymphocytes - immunology
Colleges & universities
Development and progression
Genetic aspects
Genomes
Health aspects
HIV
HIV Infections - immunology
HIV-1
HIV-1 - genetics
HIV-1 - physiology
Human immunodeficiency virus
Humans
Immune Evasion
immunodominance
Immunology
Infections
Laboratories
Lymphocytes
Male
Mathematical models
multiple infection
Mutation
Physiological aspects
Population
recombination
Recombination, Genetic
T cell
virology
Virus diseases
Virus Replication
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.
ISSN:1742-4690
1742-4690
DOI:10.1186/s12977-014-0069-9