Distinguishing characteristics of idiopathic calcium oxalate kidney stone formers with low amounts of Randall's plaque

Overgrowth of calcium oxalate on Randall's plaque is a mechanism of stone formation among idiopathic calcium oxalate stone-formers (ICSFs). It is less clear how stones form when there is little or no plaque. Participants were a consecutive cohort of ICSFs who underwent percutaneous nephroscopic...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2014-10, Vol.9 (10), p.1757-1763
Main Authors: Wang, Xiangling, Krambeck, Amy E, Williams, Jr, James C, Tang, Xiaojing, Rule, Andrew D, Zhao, Fang, Bergstralh, Eric, Haskic, Zejfa, Edeh, Samuel, Holmes, 3rd, David R, Herrera Hernandez, Loren P, Lieske, John C
Format: Article
Language:English
Subjects:
Aged
Biomarkers - analysis
Biomarkers - urine
Biopsy
Calcium Oxalate - analysis
Calcium Phosphates - analysis
Cross-Sectional Studies
Crystallization
Endoscopy
Female
Humans
Kidney - chemistry
Kidney - diagnostic imaging
Kidney - pathology
Kidney - surgery
Kidney Calculi - chemistry
Kidney Calculi - diagnosis
Kidney Calculi - etiology
Kidney Calculi - surgery
Kidney Calculi - urine
Male
Middle Aged
Obesity - complications
Original
Predictive Value of Tests
Prospective Studies
Renal Elimination
Risk Factors
Urinalysis
Urinary Tract Infections - complications
X-Ray Microtomography
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Summary:Overgrowth of calcium oxalate on Randall's plaque is a mechanism of stone formation among idiopathic calcium oxalate stone-formers (ICSFs). It is less clear how stones form when there is little or no plaque. Participants were a consecutive cohort of ICSFs who underwent percutaneous nephroscopic papillary mapping in the kidney or kidneys containing symptomatic stones and a papillary tip biopsy from a representative calyx during a stone removal procedure between 2009 and 2013. The distribution of Randall's plaque coverage was analyzed and used to divide ICSFs into those with a high (≥5%; mean, 10.5%; n=10) versus low (
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.01490214