B cells in multiple sclerosis: connecting the dots

Highlights ► Increasing evidence points towards B cells as key players in MS immunopathogenesis. ► We review potential roles of B cells in MS. ► Cellular and humoral B cell functions are probably important in CNS directed autoimmunity. ► B cells appear to be involved in disease initiation, perpetuat...

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Bibliographic Details
Published in:Current opinion in immunology 2011-12, Vol.23 (6), p.713-720
Main Authors: von Büdingen, H-Christian, Bar-Or, Amit, Zamvil, Scott S
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies - immunology
B-Lymphocytes - immunology
Blood-Brain Barrier - immunology
Humans
Multiple Sclerosis - immunology
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Summary:Highlights ► Increasing evidence points towards B cells as key players in MS immunopathogenesis. ► We review potential roles of B cells in MS. ► Cellular and humoral B cell functions are probably important in CNS directed autoimmunity. ► B cells appear to be involved in disease initiation, perpetuation, and progression.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2011.09.003