Gene polymorphisms of adducin GLY460TRP, ACE I/D, AND AGT M235T in pediatric hypertension patients

Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric po...

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Bibliographic Details
Published in:Medical science monitor 2014-09, Vol.20, p.1745-1750
Main Authors: Kaplan, İbrahim, Sancaktar, Enver, Ece, Aydın, Şen, Velat, Tekkeşin, Nilgün, Basarali, Mustafa Kemal, Kelekci, Selvi, Evliyaoglu, Osman
Format: Article
Language:English
Subjects:
Alleles
Angiotensinogen - genetics
Calmodulin-Binding Proteins - genetics
Case-Control Studies
Child
Clinical Research
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Hypertension - genetics
Male
Peptidyl-Dipeptidase A - genetics
Polymorphism, Single Nucleotide - genetics
Renal Insufficiency, Chronic - genetics
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Summary:Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension. Included in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA. There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P
ISSN:1234-1010
1643-3750
DOI:10.12659/MSM.892140