Axon plasticity in the mammalian central nervous system after injury

Highlights • Neuron-extrinsic and -intrinsic factors regulate axon plasticity. • Circuit rewiring involves formation of detour circuits or activation of latent tracts. • Rehabilitation may strengthen adaptive connections after injury. • Transneuronal tracing and 3D imaging may reveal post-injury net...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2014-10, Vol.37 (10), p.583-593
Main Authors: Chen, Meifan, Zheng, Binhai
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Axons - pathology
Central Nervous System - injuries
Central Nervous System - metabolism
Injuries
Mammals
Nerve Net - injuries
Nerve Net - metabolism
Nervous system
Neural Pathways - injuries
Neural Pathways - metabolism
Neurology
Neuronal Plasticity - physiology
Neurosciences
Recovery of Function - physiology
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Summary:Highlights • Neuron-extrinsic and -intrinsic factors regulate axon plasticity. • Circuit rewiring involves formation of detour circuits or activation of latent tracts. • Rehabilitation may strengthen adaptive connections after injury. • Transneuronal tracing and 3D imaging may reveal post-injury network alterations.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2014.08.008