The relationship between asymptomatic organ damage, and serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and Interleukin-17A (IL-17A) levels in non-diabetic hypertensive patients

• Published in: BMC nephrology 2014-10, Vol.15 (1), p.159-159, Article 159
• Main Authors: Ates, Ihsan, Ozkayar, Nihal, Akyel, Fatma, Topcuoglu, Canan, Akyel, Serdar, Barça, A Nurdan, Dede, Fatih
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Albuminuria - blood; Albuminuria - etiology; Antihypertensive Agents - therapeutic use; Apoptosis; Asymptomatic Diseases; Atherosclerosis; Cardiovascular disease; Carotid Intima-Media Thickness; Cholesterol; Cytokine TWEAK; Diabetes; Diastole; Disease Progression; Female; Females; Heart failure; Humans; Hypertension; Hypertension - blood; Hypertension - complications; Hypertension - drug therapy; Hypertensive Retinopathy - blood; Hypertensive Retinopathy - etiology; Hypertrophy, Left Ventricular - blood; Hypertrophy, Left Ventricular - etiology; Interleukin-17 - blood; Kidney diseases; Lipoproteins; Male; Middle Aged; Mortality; Nephrology; Organ Size; Patients; Regression analysis; Rheumatic diseases; Risk Factors; ROC Curve; Rodents; Studies; Systole; Triglycerides; Tumor Necrosis Factors - blood; Urine
• ISSN: 1471-2369; 1471-2369
• DOI: 10.1186/1471-2369-15-159

This study aimed to measure the serum soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and interleukin-17A (IL-17A) levels in hypertensive patients with/without asymptomatic organ damage (AOD), as well as to determine the relationship between the serum sTWEAK and IL17-A levels, and carotid intima media thickness (CIMT), proteinuria, retinopathy, and the left ventricle mass index (LVMI). The study included 159 patients diagnosed with and followed-up for primary hypertension (HT); 79 of the patients had AOD (61 female and 18 male) and 80 did not (52 female and 28 male). sTWEAK and IL-17A levels were measured in all patients. The sTWEAK level was significantly lower in the patients with AOD than in those without AOD (858.4 pg/mL vs. 1151.58 pg/mL, P = 0.001). The sTWEAK level was negatively correlated with the mean microalbuminuria level and LVMI. The median IL-17A level was significantly higher in the patients with AOD than in those without AOD (2.34 pg/mL vs. 1.80 pg/mL, P = 0.001). There was a positive correlation between mean IL-17A level, and mean microalbuminuria level, CIMT, and LVMI. Multivariate logistic regression analysis showed that patient age, sTWEAK level, and mean 24-h systolic blood pressure were predictors of AOD. The sTWEAK level was lower and IL-17A level was higher in the patients with AOD. It remains unknown if sTWEAK and IL-17A play a role in the pathophysiology of AOD. Prospective observational studies are needed to determine the precise role of sTWEAK and IL-17A in the development of target organ damage.