Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)

High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dis...

Full description

Saved in:
Bibliographic Details
Published in:Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2014-09, Vol.19 (5), p.e444-e450
Main Authors: Bachmeier, Evelin, Mazzeo, Marcelo-Adrián, López, María-Marcela, Linares, Jorge-Alberto, Jarchum, Gustavo, Wietz, Fernando-Martín, Finkelberg, Ana-Beatriz
Format: Article
Language:English
Subjects:
Adult
Aged
Bone Marrow Transplantation
Dentistry
Female
Humans
Longitudinal Studies
Male
Middle Aged
Mucositis - metabolism
Postoperative Complications - metabolism
Saliva - chemistry
Superoxide Dismutase - analysis
Uric Acid - analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High doses of chemotherapy generate DNA damage in patients undergoing bone marrow transplantation (BMT), due to the production of reactive oxygen species (ROS). In order to evaluate the local defensive effectiveness of the patient undergoing BMT, the concentrations of the antioxidants superoxide dismutase (SOD) and uric acid (UA) were measured in saliva. Basal saliva samples were collected from 20 patients undergoing BMT at the Oncology Department, Sanatorio Allende (Córdoba), in the stages: initial, prior to conditioning therapy (I); middle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F). SOD levels were determined using a RANDOX kit (RANSOD superoxide dismutase manual), and for uric acid enzymatic UOD / PAP spectrophotometric method, ( Trinder Color Kit , Wiener Lab) was used. 85% of the patients developed oral mucositis. SOD concentration in the M stage was significantly higher (p
ISSN:1698-6946
1698-4447
1698-6946
DOI:10.4317/medoral.19062