MicroRNAs and lipoproteins: A connection beyond atherosclerosis?

Abstract MicroRNAs (miRNAs) are short non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level that have been involved in the pathogenesis of a number of cardiovascular diseases. Several miRNAs have been described to finely regulate lipid metabolism and the pro...

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Bibliographic Details
Published in:Atherosclerosis 2013-04, Vol.227 (2), p.209-215
Main Authors: Norata, Giuseppe Danilo, Sala, Federica, Catapano, Alberico Luigi, Fernández-Hernando, Carlos
Format: Article
Language:English
Subjects:
Animals
atherosclerosis
Atherosclerosis - metabolism
Cardiovascular
Gene Expression Regulation
Glucose - metabolism
Humans
Lipid Metabolism
Lipoproteins
Lipoproteins - metabolism
MicroRNA
MicroRNAs - metabolism
Microvescicles
non-coding RNA
pathogenesis
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Summary:Abstract MicroRNAs (miRNAs) are short non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level that have been involved in the pathogenesis of a number of cardiovascular diseases. Several miRNAs have been described to finely regulate lipid metabolism and the progression and regression of atherosclerosis including, miR-33, miR-122. Of note miR-33a and −33b, represent one of the most interesting and attractive targets for metabolic-related disorders and anti-miR-33 approaches are under intensive investigation. More recently miRNAs were shown to exert their activities in a paracrine manner and also systemically. The latter is possible because lipid-carriers, including lipoproteins, transport and protect miRNAs from degradation in the circulation. This review will present the complex mechanism by which miRNAs regulate lipid metabolism, illustrate how their therapeutical modulation may lead to new treatments for cardiometabolic diseases, and discuss how lipoproteins and other lipid-carriers transport miRNAs in the circulation. The emerging strong connection between miRNAs, lipoproteins and lipid metabolism indicates the existence of a reciprocal modulation that might go beyond atherosclerosis.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2012.11.019