Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis

• Published in: Particle and fibre toxicology 2014-09, Vol.11 (1), p.50-50, Article 50
• Main Authors: Duan, Junchao, Yu, Yongbo, Yu, Yang, Li, Yang, Huang, Peili, Zhou, Xianqing, Peng, Shuangqing, Sun, Zhiwei
• Format: Article
• Language: English
• Subjects: Actins - metabolism; Analysis; Angiogenesis; Animals; Autophagy; Autophagy - drug effects; Cardiovascular diseases; Cell Adhesion Molecules - metabolism; Chemical properties; Coronary Vessels - drug effects; Coronary Vessels - metabolism; Coronary Vessels - ultrastructure; Cytoskeleton - drug effects; Cytoskeleton - metabolism; Cytoskeleton - ultrastructure; Disease; Dose-Response Relationship, Drug; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelial Cells - ultrastructure; Endothelium; Female; Heart; Homeostasis; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - metabolism; Human Umbilical Vein Endothelial Cells - ultrastructure; Kinases; Male; Medical research; Medicine, Experimental; Mice, Inbred ICR; Microtubule-Associated Proteins - metabolism; Mortality; Nanomaterials; Nanoparticles - toxicity; Neovascularization, Physiologic - drug effects; Outdoor air quality; Particle Size; Pericytes - drug effects; Pericytes - metabolism; Pericytes - ultrastructure; Physiological aspects; Proteins; Signal Transduction - drug effects; Silica; Silicon Dioxide - toxicity; Studies; Variance analysis
• ISSN: 1743-8977; 1743-8977
• DOI: 10.1186/s12989-014-0050-8

Given that the effects of ultrafine fractions (