Peak flow rate and death due to coronary heart disease: 30-year results from the Northwick Park Heart cohort study

Objective Numerous studies have reported that chronic obstructive pulmonary disease or impaired lung function are associated with later coronary heart disease (CHD). However, it is unclear if lung function is an independent risk factor, as many of these studies have included only limited measures of...

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Published in:Open heart 2014, Vol.1 (1), p.e000164-e000164
Main Authors: Clayton, Tim C, Meade, Tom W, Turner, Elizabeth L, De Stavola, Bianca L
Format: Article
Language:English
Subjects:
Cardiovascular disease
Coronary Artery Disease
Health risk assessment
Mortality
Studies
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Summary:Objective Numerous studies have reported that chronic obstructive pulmonary disease or impaired lung function are associated with later coronary heart disease (CHD). However, it is unclear if lung function is an independent risk factor, as many of these studies have included only limited measures of other factors associated with CHD. Methods In total 2167 men of all ages in the first Northwick Park Heart Study were followed for a median of 30 years. Cox regression models were used to assess the relationship between peak flow rate (PFR) and CHD mortality adjusted for potential confounders measured at baseline. Analyses allowed for missing data, and secondary analyses for repeat measures on some men and competing risks of CHD death. Results There were 254 CHD deaths with some evidence of an association between PFR and CHD mortality. The adjusted HRs (95% CIs) from the lowest to the highest of four PFR quartiles were 1.53 (1.04 to 2.25),
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2014-000164