Immunohistochemical study of CD44s expression in oral squamous cell carcinoma-its correlation with prognostic parameters

• Published in: Journal of oral and maxillofacial pathology : JOMFP 2014-05, Vol.18 (2), p.162-168
• Main Authors: Hema, Kn, Rao, Kavita, Devi, Hs Uma, Priya, Ns, Smitha, T, Sheethal, Hs
• Format: Article
• Language: English
• Subjects: Analysis; Gene expression; Genetic aspects; Immunohistochemistry; Original; Patient outcomes; Physiological aspects; Squamous cell carcinoma
• ISSN: 0973-029X; 1998-393X
• DOI: 10.4103/0973-029X.140722

The study aims at the observation of the immunohistochemical expression of CD44s in Oral Squamous Cell Carcinoma (OSCC) and to correlate its expression with prognostic parameters. A total of 30 cases of OSCC, - 10 cases of each well differentiated (WD SCC), moderately differentiated (MD SCC) and poorly differentiated squamous cell carcinomas (PD SCC) were included in the study. The sections were subjected to immunohistochemical study using CD44s antigen marker. The degree of intensity and distribution of CD44s immunostaining was assessed and correlated with prognostic markers such as tumor stage (tumor size), tumor grade (Broder's histological grading), tumor site, tumor thickness (histological depth of invasion) and nodal status. CD44s expression by tumor cells in OSCCs is statistically correlated with tumor grade i.e. Higher mean of CD44s immunoexpression was observed in WD SCC group (10.80 ± 3.97), followed by MD SCC group (5.90 ± 3.38) and PD SCC group showed least CD44s immunoexpression (3.70 ± 4.64). There was no statistical significance observed with respect to the other prognostic markers. Based on these observations it can be suggested that the decrease in expression of CD44s in OSCC cells may be due to the reduced cell-to-cell and cell-to-matrix adhesion, resulting in easy detachment from the rigid constitution. Low expression of CD44s in OSCC tissues may be an indicator of tumor invasion and high metastatic potential.