Are effector memory T cells the key to an effective HIV/AIDS vaccine?

Graphical Abstract Tried and true vaccine approaches to HIV have failed. Could Cytomegalovirus and its “goldilocks” level of viral persistence maintain robust, “effector memory” T‐cell responses and finally produce an effective, early‐intervention vaccine against HIV?

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Bibliographic Details
Published in:EMBO reports 2014-08, Vol.15 (8), p.820-821
Main Author: Picker, Louis J
Format: Article
Language:English
Subjects:
AIDS Vaccines
Animals
EMBO19
EMBO52
HIV - immunology
HIV Infections - prevention & control
Humans
Immunologic Memory
Opinion
T-Lymphocyte Subsets
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Description
Summary:Graphical Abstract Tried and true vaccine approaches to HIV have failed. Could Cytomegalovirus and its “goldilocks” level of viral persistence maintain robust, “effector memory” T‐cell responses and finally produce an effective, early‐intervention vaccine against HIV?
ISSN:1469-221X
1469-3178
DOI:10.15252/embr.201439052