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Liaison between natural killer cells and dendritic cells in human gestation
A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN~ dendritic cells （DCs） and CD56＋ n...
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| Published in: | Cellular & molecular immunology 2014-09, Vol.11 (5), p.449-455 |
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| cites | cdi_FETCH-LOGICAL-c534t-1272933e490ec6d49b3d440c693d647cc344bc0cae3a02e8c51ab199ccb452013 |
| container_end_page | 455 |
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| container_start_page | 449 |
| container_title | Cellular & molecular immunology |
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| creator | Ester Leno-Duran Raquel Mufioz-Fernfindez Enrique Garcia Olivares Irene Tirado-GonzAlez |
| description | A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN~ dendritic cells （DCs） and CD56＋ natural killer （NK） cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua. |
| doi_str_mv | 10.1038/cmi.2014.36 |
| format | article |
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Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN~ dendritic cells （DCs） and CD56＋ natural killer （NK） cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/cmi.2014.36</identifier><identifier>PMID: 24954224</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adaptation ; Antibodies ; Antigens ; Biomedical and Life Sciences ; Biomedicine ; CD56 antigen ; CD56 Antigen - metabolism ; Cell Adhesion Molecules - metabolism ; Cell Communication ; Cell differentiation ; DC-SIGN protein ; Decidua ; Dendritic cells ; Dendritic Cells - immunology ; Female ; Fetuses ; Humans ; Immune Tolerance ; Immunological tolerance ; Immunology ; Immunomodulation ; Killer Cells, Natural - immunology ; Lectins, C-Type - metabolism ; Medical Microbiology ; Microbiology ; Natural killer cells ; Pregnancy ; Receptors, Cell Surface - metabolism ; Review ; Uterus ; Uterus - immunology ; Vaccine ; 免疫细胞 ; 免疫耐受 ; 早期妊娠 ; 树突状细胞 ; 树突细胞 ; 细胞类型 ; 联络 ; 自然杀伤细胞</subject><ispartof>Cellular & molecular immunology, 2014-09, Vol.11 (5), p.449-455</ispartof><rights>Chinese Society of Immunology and The University of Science and Technology 2014</rights><rights>Copyright Nature Publishing Group Sep 2014</rights><rights>Chinese Society of Immunology and The University of Science and Technology 2014.</rights><rights>Copyright © 2014 Chinese Society of Immunology and The University of Science and Technology 2014 Chinese Society of Immunology and The University of Science and Technology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-1272933e490ec6d49b3d440c693d647cc344bc0cae3a02e8c51ab199ccb452013</citedby><cites>FETCH-LOGICAL-c534t-1272933e490ec6d49b3d440c693d647cc344bc0cae3a02e8c51ab199ccb452013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/87787X/87787X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197206/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197206/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24954224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ester Leno-Duran Raquel Mufioz-Fernfindez Enrique Garcia Olivares Irene Tirado-GonzAlez</creatorcontrib><title>Liaison between natural killer cells and dendritic cells in human gestation</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><description>A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. Among several immunocompetent cell types present within the human maternal/fetal interface, DC-SIGN~ dendritic cells （DCs） and CD56＋ natural killer （NK） cells are of major importance for early pregnancy maintenance, not only generating maternal immunological tolerance but also regulating stromal cell differentiation. Previous reports show the presence of NK-DC cell conjugates in first trimester human decidua, suggesting that these cells may play a role in the modulation of the local immune response within the uterus. While effective immunity is necessary to protect the mother from harmful pathogens, some form of tolerance must be activated to avoid an immune response against fetal antigens. This review article discusses current evidence concerning the functions of DC and NK cells in pregnancy and their liaison in human decidua.</description><subject>Adaptation</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>CD56 antigen</subject><subject>CD56 Antigen - metabolism</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell Communication</subject><subject>Cell differentiation</subject><subject>DC-SIGN protein</subject><subject>Decidua</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunological tolerance</subject><subject>Immunology</subject><subject>Immunomodulation</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lectins, C-Type - metabolism</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Natural killer cells</subject><subject>Pregnancy</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Review</subject><subject>Uterus</subject><subject>Uterus - immunology</subject><subject>Vaccine</subject><subject>免疫细胞</subject><subject>免疫耐受</subject><subject>早期妊娠</subject><subject>树突状细胞</subject><subject>树突细胞</subject><subject>细胞类型</subject><subject>联络</subject><subject>自然杀伤细胞</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkc1v1DAQxS0EokvhxB1FcEGCLPZ47MSXSqjio2IlLu3Zchx31yWxWzsB9b-vV7usCkL0ZMnzmzfz5hHyktElo7z9YEe_BMpwyeUjsgCKUFMA-ZgsmGygbmTLjsiznK8oFS02-JQcASqBALgg31be-BxD1bnpl3OhCmaakxmqH34YXKqsG4ZcmdBXvQt98pO3-z8fqs08mlCtXZ7M5GN4Tp5cmiG7F_v3mFx8_nR--rVeff9ydvpxVVvBcaoZNKA4d6ios7JH1fEekVqpeC-xsZYjdpZa47ih4FormOmYUtZ2KIpRfkxOdrrXcze63rowlY31dfKjSbc6Gq__rAS_0ev4UyNTDVBZBN7uBVK8mcv6evR568oEF-esmZQtiFY1_GFUCEWpkkIV9M1f6FWcUyiX0NDIkpQou_-PYk0rBGMAolDvdpRNMefkLg_uGNXb1HVJXW9T13zr59X9gxzY3zEX4P0OyKUU1i7dG_pPvdf76ZsY1jel4yApJSByhJbfAeEgwLk</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Ester Leno-Duran Raquel Mufioz-Fernfindez Enrique Garcia Olivares Irene Tirado-GonzAlez</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20140901</creationdate><title>Liaison between natural killer cells and dendritic cells in human gestation</title><author>Ester Leno-Duran Raquel Mufioz-Fernfindez Enrique Garcia Olivares Irene Tirado-GonzAlez</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-1272933e490ec6d49b3d440c693d647cc344bc0cae3a02e8c51ab199ccb452013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adaptation</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>CD56 antigen</topic><topic>CD56 Antigen - metabolism</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell Communication</topic><topic>Cell differentiation</topic><topic>DC-SIGN protein</topic><topic>Decidua</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Female</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunological tolerance</topic><topic>Immunology</topic><topic>Immunomodulation</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lectins, C-Type - metabolism</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Natural killer cells</topic><topic>Pregnancy</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Review</topic><topic>Uterus</topic><topic>Uterus - immunology</topic><topic>Vaccine</topic><topic>免疫细胞</topic><topic>免疫耐受</topic><topic>早期妊娠</topic><topic>树突状细胞</topic><topic>树突细胞</topic><topic>细胞类型</topic><topic>联络</topic><topic>自然杀伤细胞</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ester Leno-Duran Raquel Mufioz-Fernfindez Enrique Garcia Olivares Irene Tirado-GonzAlez</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ester Leno-Duran Raquel Mufioz-Fernfindez Enrique Garcia Olivares Irene Tirado-GonzAlez</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liaison between natural killer cells and dendritic cells in human gestation</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><addtitle>Cellular ＆ Molecular Immunology</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>11</volume><issue>5</issue><spage>449</spage><epage>455</epage><pages>449-455</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>A successful pregnancy relies on immunological adaptations that allow the fetus to grow and develop in the uterus, despite being recognized by maternal immune cells. 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| ispartof | Cellular & molecular immunology, 2014-09, Vol.11 (5), p.449-455 |
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| subjects | Adaptation Antibodies Antigens Biomedical and Life Sciences Biomedicine CD56 antigen CD56 Antigen - metabolism Cell Adhesion Molecules - metabolism Cell Communication Cell differentiation DC-SIGN protein Decidua Dendritic cells Dendritic Cells - immunology Female Fetuses Humans Immune Tolerance Immunological tolerance Immunology Immunomodulation Killer Cells, Natural - immunology Lectins, C-Type - metabolism Medical Microbiology Microbiology Natural killer cells Pregnancy Receptors, Cell Surface - metabolism Review Uterus Uterus - immunology Vaccine 免疫细胞 免疫耐受 早期妊娠 树突状细胞 树突细胞 细胞类型 联络 自然杀伤细胞 |
| title | Liaison between natural killer cells and dendritic cells in human gestation |
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