Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection

• Published in: World journal of gastrointestinal oncology 2014-10, Vol.6 (10), p.413-419
• Main Authors: Shantha Kumara, H M C, Myers, Elizabeth A, Herath, Sonali Ac, Jang, Joon Ho, Njoh, Linda, Yan, Xiaohong, Kirchoff, Daniel, Cekic, Vesna, Luchtefeld, Martin, Whelan, Richard L
• Format: Article
• Language: English
• Subjects: angio-genesis; cancer; chemotactic; Colorectal; invasive; Minimally; Monocyte; protein-1; resection; Retrospective Study
• ISSN: 1948-5204; 1948-5204
• DOI: 10.4251/wjgo.v6.i10.413

AIM: To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer(CRC) and benign patients and postoperatively after CRC resection.METHODS: A plasma bank was screened for minimally invasive colorectal cancer resection(MICR) for CRC and benign disease(BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples(postoperative day 7-27) were available. Monocyte chemotactic protein-1(MCP-1) levels(pg/mL) were determined via enzyme linked immuno-absorbent assay. RESULTS: One hundred and two CRC and 86 BEN patients were studied. The CRC patient’s median preoperative MCP-1 level(283.1, CI: 256.0, 294.3) was higher than the BEN group level(227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1(446.3, CI: 418.0, 520.1), postoperative day 3(342.7, CI: 320.4, 377.4), postoperative day 7-13(326.5, CI: 299.4, 354.1), postoperative day 14-20(361.6, CI: 287.8, 407.9), and postoperative day 21-27(318.1, CI: 287.2, 371.6; P < 0.001 for all). CONCLUSION: Preoperative MCP-1 levels were higher in CRC patients(vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis.