Human-Specific Duplication and Mosaic Transcripts: The Recent Paralogous Structure of Chromosome 22

In recent decades, comparative chromosomal banding, chromosome painting, and gene-order studies have shown strong conservation of gross chromosome structure and gene order in mammals. However, findings from the human genome sequence suggest an unprecedented degree of recent (

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Bibliographic Details
Published in:American journal of human genetics 2002-01, Vol.70 (1), p.83-100
Main Authors: Bailey, Jeffrey A., Yavor, Amy M., Viggiano, Luigi, Misceo, Doriana, Horvath, Juliann E., Archidiacono, Nicoletta, Schwartz, Stuart, Rocchi, Mariano, Eichler, Evan E.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Centromere - genetics
chromosome 14
Chromosome 22
Chromosome aberrations
Chromosomes, Human, Pair 14 - genetics
Chromosomes, Human, Pair 22 - genetics
Evolution, Molecular
Exons - genetics
Gene Dosage
Gene Duplication
Genes, Duplicate - genetics
Humans
In Situ Hybridization, Fluorescence
Introns - genetics
Medical genetics
Medical sciences
Mosaicism - genetics
Primates - genetics
RNA, Messenger - analysis
RNA, Messenger - genetics
Species Specificity
Time Factors
Transcription, Genetic - genetics
Translocation, Genetic - genetics
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Description
Summary:In recent decades, comparative chromosomal banding, chromosome painting, and gene-order studies have shown strong conservation of gross chromosome structure and gene order in mammals. However, findings from the human genome sequence suggest an unprecedented degree of recent (
ISSN:0002-9297
1537-6605
DOI:10.1086/338458