Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein

Objective To investigate the relationship between post-operative cognitive dysfunction (POCD) and regional cerebral oxygen saturation (rSO 2 ) and β-amyloid protein (Aβ) in patients undergoing laparoscopic pancreaticoduodenectomy. Methods Fifty patients undergoing elective laparoscopic pancreaticodu...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2014-10, Vol.15 (10), p.870-878
Main Authors: Li, Xi-ming, Shao, Ming-tao, Wang, Jian-juan, Wang, Yue-lan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amyloid beta-Peptides - blood
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Brain Ischemia - blood
Brain Ischemia - diagnosis
Brain Ischemia - etiology
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Female
Humans
Laparoscopy - adverse effects
Male
Middle Aged
Oximetry - methods
Oxygen - analysis
Pancreaticoduodenectomy - adverse effects
Reproducibility of Results
Risk Assessment
Sensitivity and Specificity
Treatment Outcome
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Summary:Objective To investigate the relationship between post-operative cognitive dysfunction (POCD) and regional cerebral oxygen saturation (rSO 2 ) and β-amyloid protein (Aβ) in patients undergoing laparoscopic pancreaticoduodenectomy. Methods Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO 2 intra-operatively. Before anesthesia induction ( t 0 ), at the beginning of laparoscopy ( t 1 ), and at the time of pneumoperitoneum 120 min ( t 2 ), pneumoperitoneum 240 min ( t 3 ), pneumoperitoneum 480 min ( t 4 ), the end of pneumoperitoneum ( t 5 ), and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay (ELISA). Results Twenty-one cases of the fifty patients suffered from POCD after operation. We found that the maximum percentage drop in rSO 2 (rSO 2, %max ) was significantly higher in the POCD group than in the non-POCD group. The rSO 2, %max value of over 10.2% might be a potential predictor of neurocognitive injury for those patients. In the POCD group, the plasma Aβ levels after 24 h were significantly higher than those of pre-operative values ( P
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.B1400130